Klf7 MGI Mouse Gene Detail - MGI:1935151 - Kruppel-like transcription factor 7 (ubiquitous)

Symbol

Klf7
Name

Kruppel-like transcription factor 7 (ubiquitous)
Synonyms

9830124P08Rik

Feature Type

protein coding gene
IDs

MGI:1935151
NCBI Gene: 93691
Alliance

gene page
Transcription Start Sites

21 TSS

Sequence Map

Chr1:64068606-64161441 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 32.31 cM, cytoband C1-C3
Mapping Data

2 experiments

SNPs within 2kb

1984 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1935151	protein coding gene	Chr1:64068606-64161504 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016094	protein coding gene	Chr1:64203619-64299549 (-)
A/J	MGP_AJ_G0016077	protein coding gene	Chr1:61933955-62027131 (-)
AKR/J	MGP_AKRJ_G0016034	protein coding gene	Chr1:63660082-63748259 (-)
BALB/cJ	MGP_BALBcJ_G0016032	protein coding gene	Chr1:62022500-62115832 (-)
C3H/HeJ	MGP_C3HHeJ_G0015864	protein coding gene	Chr1:63948165-64041560 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016485	protein coding gene	Chr1:66684264-66778548 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014206	protein coding gene	Chr1:58009234-58104531 (-)
CAST/EiJ	MGP_CASTEiJ_G0015447	protein coding gene	Chr1:63211341-63306128 (-)
CBA/J	MGP_CBAJ_G0015836	protein coding gene	Chr1:68846507-68949006 (-)
DBA/2J	MGP_DBA2J_G0015937	protein coding gene	Chr1:61354748-61447849 (-)
FVB/NJ	MGP_FVBNJ_G0015940	protein coding gene	Chr1:60631838-60726784 (-)
LP/J	MGP_LPJ_G0016009	protein coding gene	Chr1:65097778-65198582 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015960	protein coding gene	Chr1:71734711-71834534 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016532	protein coding gene	Chr1:63653031-63752859 (-)
PWK/PhJ	MGP_PWKPhJ_G0015234	protein coding gene	Chr1:60724118-60819467 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015013	protein coding gene	Chr1:63157189-63250065 (-)
WSB/EiJ	MGP_WSBEiJ_G0015509	protein coding gene	Chr1:63359185-63455214 (-)

Human Ortholog

KLF7, KLF transcription factor 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KLF7, KLF transcription factor 7
Synonyms

UKLF
Links

HGNC:6350

NCBI Gene ID: 8609

neXtProt AC: NX_O75840

UniProt: O75840
Chr Location

2q33.3; chr2:207074137-207173856 (-) GRCh38

MGI Vertebrate Homology

Klf7 stringent orthology
1 human;1 mouse;2 zebrafish
HCOP

vertebrate homology predictions: KLF7
Gene Tree

Klf7

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Phenotype Summary

28 phenotypes from 2 alleles in 2 genetic backgrounds
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

2
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Klf7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice die within 3 days of life, showing lack of gastic milk, hypopnea, cyanosis, olfactory bulb hypoplasia, no response to tail clamping, impaired axon projection in the olfactory and visual systems, cerebral cortex and hippocampus, and reduced dendritic branching in the hippocampus.

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All GO Annotations

35
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

978
Tissues

160
cDNA Data

15
Literature Summary

23

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase klf7

ZFIN klf7a, klf7b

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All Sequences

65
RefSeq

14
UniProt

5
CCDS

CCDS15003.1

Ensembl

ENSMUSG00000025959 (Evidence)
NCBI Gene

93691

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025959	Ensembl Gene Model \| MGI Sequence Detail	92836	C57BL/6J	± kb
transcript	ENSMUST00000114086	Ensembl \| MGI Sequence Detail	7662	Not Applicable
polypeptide	ENSMUSP00000109720	Ensembl \| MGI Sequence Detail	301	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000009367 krueppel-like factor 7

(term hierarchy)
InterPro Domains

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 21

Genomic 1

cDNA 15

Primer pair 3

Other 2

Microarray probesets 9

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MGI:2445036

Summaries

All 67

Developmental Gene Expression 23

Gene Ontology 8

Phenotypes 22
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:354191 Kc R, et al., Multimodal Hox5 activity generates motor neuron diversity. Commun Biol. 2024 Sep 17;7(1):1166

TSS for Klf7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11915	Chr1:64161415-64161480 (-)	-7 bp
Tssr11914	Chr1:64160813-64160835 (-)	617 bp
Tssr11913	Chr1:64160615-64160622 (-)	822 bp
Tssr11912	Chr1:64160557-64160611 (-)	857 bp
Tssr11911	Chr1:64160530-64160541 (-)	905 bp
Tssr11910	Chr1:64160474-64160483 (-)	962 bp
Tssr11909	Chr1:64160436-64160471 (-)	987 bp
Tssr11908	Chr1:64160396-64160411 (-)	1,037 bp
Tssr11907	Chr1:64160350-64160362 (-)	1,085 bp
Tssr11906	Chr1:64160135-64160203 (-)	1,272 bp
Tssr11905	Chr1:64146347-64146352 (-)	15,091 bp
Tssr11904	Chr1:64118132-64118148 (-)	43,301 bp
Tssr11903	Chr1:64081488-64081509 (-)	79,942 bp
Tssr11902	Chr1:64074901-64074926 (-)	86,527 bp
Tssr11901	Chr1:64073006-64073022 (-)	88,427 bp
Tssr11900	Chr1:64072691-64072711 (-)	88,740 bp
Tssr11899	Chr1:64069520-64069540 (-)	91,911 bp
Tssr11898	Chr1:64069448-64069461 (-)	91,986 bp
Tssr11897	Chr1:64069422-64069432 (-)	92,014 bp
Tssr11896	Chr1:64069342-64069357 (-)	92,091 bp
Tssr11895	Chr1:64069324-64069335 (-)	92,111 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24