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Clec2d Gene Detail
Summary
  • Symbol
    Clec2d
  • Name
    C-type lectin domain family 2, member d
  • Synonyms
    Clr-b, Clrb, Ocil
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135589
    NCBI Gene: 93694
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:129157578-129163497 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 63.16 cM, cytoband F3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    388 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135589
 protein coding gene Chr6:129157578-129163498 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031341
 protein coding gene Chr6:132835555-132844328 (+)
A/J MGP_AJ_G0031312
 protein coding gene Chr6:127750178-127756349 (+)
AKR/J MGP_AKRJ_G0031240
 protein coding gene Chr6:131234139-131239976 (+)
BALB/cJ MGP_BALBcJ_G0031319
 protein coding gene Chr6:127389280-127401617 (+)
C3H/HeJ MGP_C3HHeJ_G0031043
 protein coding gene Chr6:131429053-131435593 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031778
 protein coding gene Chr6:136313469-136319389 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028924
 protein coding gene Chr6:125265539-125271702 (+)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0031158
 protein coding gene Chr6:126497482-126505525 (+)
FVB/NJ MGP_FVBNJ_G0031110
 protein coding gene Chr6:125582371-125591801 (+)
LP/J MGP_LPJ_G0031240
 protein coding gene Chr6:133042782-133055839 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031146
 protein coding gene Chr6:145276040-145284127 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031811
 protein coding gene Chr6:131298622-131304264 (+)
PWK/PhJ MGP_PWKPhJ_G0030138
 protein coding gene Chr6:124986168-124993297 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029968
 protein coding gene Chr6:129324863-129331862 (+)
WSB/EiJ MGP_WSBEiJ_G0030506
 protein coding gene Chr6:131366798-131501428 (+)



Homology
more
  • Human Ortholog
    CLEC2D, C-type lectin domain family 2 member D
  • Vertebrate Orthologs
    9
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLEC2D, C-type lectin domain family 2 member D
  • Synonyms
    CLAX, LLT1, OCIL
  • Links
    NCBI Gene ID: 29121
    neXtProt AC: NX_Q9UHP7
    UniProt: Q9UHP7

  • Chr Location
    12p13.31; chr12:9664969-9699553 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Enhanced osteoclastic activity in the bone of homozygous null mice leads to osteopenia and high serum calcium levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    796
  • Tissues
    38
  • cDNA Data
    16
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030157 Ensembl Gene Model | MGI Sequence Detail 5920 C57BL/6J ±  kb
    transcript ENSMUST00000032260 Ensembl | MGI Sequence Detail 1213 Not Applicable  
    polypeptide ENSMUSP00000032260 Ensembl | MGI Sequence Detail 207 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • PDB
      6E7D
    • InterPro Domains
      IPR050828 C-type lectin and matrix domain-containing protein
      IPR016187 C-type lectin fold
      IPR001304 C-type lectin-like
      IPR016186 C-type lectin-like/link domain superfamily
      IPR033992 Natural killer cell receptor-like, C-type lectin-like domain
    • GlyGen
      Q91V08 1 site
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 16
      Primer pair 3
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 6
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:69269 Zhou H, et al., A novel osteoblast-derived C-type lectin that inhibits osteoclast formation. J Biol Chem. 2001 May 4;276(18):14916-23
    • Latest
      J:343050 Li F, et al., C-type lectin receptor 2d forms homodimers and heterodimers with TLR2 to negatively regulate IRF5-mediated antifungal immunity. Nat Commun. 2023 Oct 23;14(1):6718
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory