Pard3 MGI Mouse Gene Detail - MGI:2135608 - par-3 family cell polarity regulator

Symbol

Pard3
Name

par-3 family cell polarity regulator
Synonyms

ASIP, D8Ertd580e, Par3, PAR-3, Pard3a

Feature Type

protein coding gene
IDs

MGI:2135608
NCBI Gene: 93742
Alliance

genome feature page
Transcription Start Sites

21 TSS

Sequence Map

Chr8:127790643-128338767 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 74.66 cM, cytoband E2
Mapping Data

4 experiments

SNPs within 2kb

14338 from dbSNP Build 142
Strain Annotations

37

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2135608	protein coding gene	Chr8:127790131-128338767 (+)
129S1/SvImJ	ENSMUSGG00200054801	protein coding gene	Chr8:122157773-122263553 (+)
129S1/SvImJ	ENSMUSGG00200054800	protein coding gene	Chr8:122050198-122126870 (+)
129S1/SvImJ	ENSMUSG00200004605	protein coding gene	Chr8:122292842-122419738 (+)
A/J	ENSMUSG00195003701	protein coding gene	Chr8:122571522-122698463 (+)
A/J	ENSMUSGG00195055325	protein coding gene	Chr8:122436497-122542229 (+)
A/J	ENSMUSGG00195055417	protein coding gene	Chr8:122328943-122405585 (+)
AKR/J	ENSMUSGG00220054733	protein coding gene	Chr8:122516814-122593478 (+)
AKR/J	ENSMUSGG00220054732	protein coding gene	Chr8:122624395-122730138 (+)
AKR/J	ENSMUSG00220001667	protein coding gene	Chr8:122759432-122886391 (+)
BALB/cJ	ENSMUSGG00180055131	protein coding gene	Chr8:122481206-122586939 (+)
BALB/cJ	ENSMUSGG00180055132	protein coding gene	Chr8:122373666-122450315 (+)
BALB/cJ	ENSMUSG00180000900	protein coding gene	Chr8:122616235-122743165 (+)
C3H/HeJ	ENSMUSG00175005078	protein coding gene	Chr8:122692928-122819855 (+)
C3H/HeJ	ENSMUSGG00175054970	protein coding gene	Chr8:122557892-122663634 (+)
C3H/HeJ	ENSMUSGG00175055063	protein coding gene	Chr8:122450352-122526997 (+)
C57BL/6NJ	ENSMUSGG00215055726	protein coding gene	Chr8:122132027-122237810 (+)
C57BL/6NJ	ENSMUSG00215000684	protein coding gene	Chr8:122267080-122393948 (+)
C57BL/6NJ	ENSMUSGG00215055682	protein coding gene	Chr8:122024492-122101149 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031733	protein coding gene	Chr8:118178479-118720909 (+)
CAST/EiJ	no annotation
CBA/J	ENSMUSG00210013907	protein coding gene	Chr8:122579475-122706241 (+)
CBA/J	ENSMUSGG00210054919	protein coding gene	Chr8:122346458-122423128 (+)
DBA/2J	ENSMUSG00185035620	protein coding gene	Chr8:128898459-129025227 (+)
DBA/2J	ENSMUSGG00185057445	protein coding gene	Chr8:128665480-128742159 (+)
FVB/NJ	ENSMUSGG00205054239	protein coding gene	Chr8:121431273-121537066 (+)
FVB/NJ	ENSMUSGG00205054238	protein coding gene	Chr8:121323753-121400398 (+)
FVB/NJ	ENSMUSG00205018671	protein coding gene	Chr8:121566331-121693209 (+)
JF1/MsJ	no annotation
LP/J	ENSMUSG00230006618	protein coding gene	Chr8:132475272-132602173 (+)
LP/J	ENSMUSGG00230055741	protein coding gene	Chr8:132340215-132445985 (+)
LP/J	ENSMUSGG00230055700	protein coding gene	Chr8:132232668-132309325 (+)
NOD/ShiLtJ	ENSMUSGG00190054907	protein coding gene	Chr8:122467137-122543780 (+)
NOD/ShiLtJ	ENSMUSGG00190054908	protein coding gene	Chr8:122574646-122680417 (+)
NOD/ShiLtJ	ENSMUSG00190006460	protein coding gene	Chr8:122709684-122844016 (+)
NZO/HlLtJ	ENSMUSG00225019427	protein coding gene	Chr8:135830223-135957093 (+)
NZO/HlLtJ	ENSMUSGG00225055652	protein coding gene	Chr8:135587675-135664294 (+)
NZO/HlLtJ	ENSMUSGG00225055481	protein coding gene	Chr8:135695178-135800956 (+)
PWK/PhJ	no annotation
SPRET/EiJ	ENSMSPG00010001608	protein coding gene	Chr8:124360533-124929800 (+)
WSB/EiJ	no annotation

Human Ortholog

PARD3, par-3 family cell polarity regulator

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PARD3, par-3 family cell polarity regulator
Synonyms

ASIP, Baz, PAR3, PAR3alpha, PARD-3, PARD3A, PPP1R118, SE2-5L16, SE2-5LT1, SE2-5T2
Links

HGNC:16051

NCBI Gene ID: 56288

UniProt: Q8TEW0
Chr Location

10p11.22-p11.21; chr10:34109560-34815419 (-) GRCh38

MGI Vertebrate Homology

Pard3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PARD3
Gene Tree

Pard3

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Phenotype Summary

25 phenotypes from 3 alleles in 5 genetic backgrounds
3 phenotypes from multigenic genotypes
42 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

53
Endonuclease-mediated

7
Gene trapped

38
Targeted

8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

100 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit embryonic lethality at E12.5 associated with growth retardation, abnormal heart development, and abnormal epicardial cell development.

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All GO Annotations

82
GO References

22

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

757
Tissues

94
cDNA Data

131
Literature Summary

146

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pard3

ZFIN pard3ab

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All Sequences

208
RefSeq

50
UniProt

28
CCDS

CCDS22788.1, CCDS22789.1, CCDS40523.1, CCDS52712.1, CCDS80945.1, CCDS80946.1

Ensembl

ENSMUSG00000025812 (Evidence)
NCBI Gene

93742

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025812	Ensembl Gene Model \| MGI Sequence Detail	548125	C57BL/6J	± kb
transcript	ENSMUST00000160272	Ensembl \| MGI Sequence Detail	5815	Not Applicable
polypeptide	ENSMUSP00000125453	Ensembl \| MGI Sequence Detail	1334	Not Applicable

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UniProt

28 Sequences
Protein Ontology

PR:000012279 partitioning defective 3

(term hierarchy)
PDB

2KOH, 2KOJ
InterPro Domains

IPR021922 Par3/HAL, N-terminal

IPR052213 Partitioning defective 3

IPR001478 PDZ domain

IPR036034 PDZ superfamily
GlyGen

Q99NH2 1 site, 1 O-linked glycan (1 site)

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All nucleic 133

cDNA 132

Primer pair 1

Antibodies 17

Microarray probesets 9

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MGI:1261826, MGI:2142456, MGI:2142486

Summaries

All 273

Developmental Gene Expression 146

Gene Ontology 22

Phenotypes 42
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:390615 Yang L, et al., PAR3-mediated coordination of hepatocyte proliferation, maturation, and architecture in liver development and regeneration. Nat Commun. 2026 Jun 12;17(1)

TSS for Pard3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr80125	Chr8:127790391-127790447 (+)	-224 bp
Tssr80126	Chr8:127790647-127790666 (+)	14 bp
Tssr2740	Chr8:127790742-127790756 (+)	106 bp
Tssr80127	Chr8:127790772-127790836 (+)	161 bp
Tssr80128	Chr8:127790839-127790855 (+)	204 bp
Tssr80129	Chr8:127790857-127790858 (+)	215 bp
Tssr80130	Chr8:127795845-127795865 (+)	5,212 bp
Tssr80131	Chr8:127820321-127820324 (+)	29,680 bp
Tssr80132	Chr8:127822426-127822430 (+)	31,785 bp
Tssr80133	Chr8:127838266-127838268 (+)	47,624 bp
Tssr80134	Chr8:127898141-127898157 (+)	107,506 bp
Tssr80135	Chr8:127905785-127905789 (+)	115,144 bp
Tssr80136	Chr8:127960802-127960813 (+)	170,165 bp
Tssr80137	Chr8:127960912-127960997 (+)	170,312 bp
Tssr80138	Chr8:127995461-127995465 (+)	204,820 bp
Tssr2741	Chr8:128105587-128105595 (+)	314,948 bp
Tssr80139	Chr8:128174150-128174159 (+)	383,512 bp
Tssr80141	Chr8:128247677-128247682 (+)	457,037 bp
Tssr80142	Chr8:128267196-128267199 (+)	476,555 bp
Tssr80143	Chr8:128272661-128272666 (+)	482,021 bp
Tssr80144	Chr8:128306173-128306191 (+)	515,539 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24