Immp2l MGI Mouse Gene Detail - MGI:2135611 - IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)

Symbol

Immp2l
Name

IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
Synonyms

IMP2

Feature Type

protein coding gene
IDs

MGI:2135611
NCBI Gene: 93757
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr12:41074089-42002371 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 18.69 cM, cytoband B3
Mapping Data

3 experiments

SNPs within 2kb

23871 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2135611	protein coding gene	Chr12:41074060-42002371 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019707	protein coding gene	Chr12:39475713-40461675 (+)
A/J	MGP_AJ_G0019672	protein coding gene	Chr12:38172459-39073302 (+)
AKR/J	MGP_AKRJ_G0019643	protein coding gene	Chr12:39335380-40286703 (+)
BALB/cJ	MGP_BALBcJ_G0019650	protein coding gene	Chr12:38389184-39327288 (+)
C3H/HeJ	MGP_C3HHeJ_G0019454	protein coding gene	Chr12:39263129-40243786 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020097	protein coding gene	Chr12:40634889-41610962 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017722	protein coding gene	Chr12:37287998-38167793 (+)
CAST/EiJ	MGP_CASTEiJ_G0019007	protein coding gene	Chr12:34448864-35418622 (+)
CBA/J	MGP_CBAJ_G0019426	protein coding gene	Chr12:42016021-43061556 (+)
DBA/2J	MGP_DBA2J_G0019539	protein coding gene	Chr12:38018180-38946129 (+)
FVB/NJ	MGP_FVBNJ_G0019528	protein coding gene	Chr12:37645850-38536809 (+)
LP/J	MGP_LPJ_G0019609	protein coding gene	Chr12:39469746-40422100 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019564	protein coding gene	Chr12:42162705-43294965 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020137	protein coding gene	Chr12:38887677-39850724 (+)
PWK/PhJ	MGP_PWKPhJ_G0018774	protein coding gene	Chr12:32707222-33635554 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018564	protein coding gene	Chr12:33558862-34498045 (+)
WSB/EiJ	MGP_WSBEiJ_G0019057	protein coding gene	Chr12:39207248-40179686 (+)

Human Ortholog

IMMP2L, inner mitochondrial membrane peptidase subunit 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IMMP2L, inner mitochondrial membrane peptidase subunit 2
Synonyms

IMMP2L-IT1, IMP2, IMP2-LIKE
Links

HGNC:14598

NCBI Gene ID: 83943

neXtProt AC: NX_Q96T52

UniProt: Q96T52
Chr Location

7q31.1; chr7:110662644-111562517 (-) GRCh38

MGI Vertebrate Homology

Immp2l stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: IMMP2L
Gene Tree

Immp2l

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Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

17 phenotypes from 3 alleles in 3 genetic backgrounds
11 phenotypes from multigenic genotypes
44 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

50
Chemically induced (ENU)

1
Endonuclease-mediated

4
Gene trapped

42
Targeted

1
Transgenic

2
Incidental Mutations

APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a transgenic gene disruption exhibit reduced fertility, abnormal cellular respiration, and decreased body weight.

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All GO Annotations

23
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

6

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

51
RefSeq

10
UniProt

2
CCDS

CCDS83961.1

Ensembl

ENSMUSG00000056899 (Evidence)
NCBI Gene

93757

			Length	Strain/Species	Flank
genomic	ENSMUSG00000056899	Ensembl Gene Model \| MGI Sequence Detail	928283	C57BL/6J	± kb
transcript	ENSMUST00000132121	Ensembl \| MGI Sequence Detail	1147	Not Applicable
polypeptide	ENSMUSP00000118779	Ensembl \| MGI Sequence Detail	175	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009013 mitochondrial inner membrane protease subunit 2

(term hierarchy)
EC

3.4.21.-
InterPro Domains

IPR036286 LexA/Signal peptidase-like superfamily

IPR037730 Mitochondrial inner membrane protease subunit 2

IPR019533 Peptidase S26

IPR000223 Peptidase S26A, signal peptidase I

IPR019758 Peptidase S26A, signal peptidase I, conserved site
GlyGen

Q8BPT6 1 site, 1 O-linked glycan (1 site)

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All nucleic 6

cDNA 6

Microarray probesets 4

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MGI:2144909, MGI:2153982

Summaries

All 75

Diseases 1

Gene Ontology 7

Phenotypes 44
Earliest

J:31937 Newberg MH, et al., Importance of MHC class 1 alpha2 and alpha3 domains in the recognition of self and non-self MHC molecules. J Immunol. 1996 Apr 1;156(7):2473-80
Latest

J:346038 Clarke RA, et al., Immp2l Enhances the Structure and Function of Mitochondrial Gpd2 Dehydrogenase. Int J Mol Sci. 2024 Jan 12;25(2)

TSS for Immp2l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113343	Chr12:41074095-41074133 (+)	25 bp
Tssr113344	Chr12:41074354-41074366 (+)	271 bp
Tssr113345	Chr12:41074378-41074389 (+)	295 bp
Tssr113346	Chr12:41201089-41201101 (+)	127,006 bp
Tssr113347	Chr12:41242886-41242889 (+)	168,799 bp
Tssr113348	Chr12:41303692-41303703 (+)	229,609 bp
Tssr113349	Chr12:41307283-41307284 (+)	233,195 bp
Tssr113350	Chr12:41311053-41311057 (+)	236,966 bp
Tssr113351	Chr12:41313233-41313237 (+)	239,146 bp
Tssr113352	Chr12:41445736-41445741 (+)	371,650 bp
Tssr113353	Chr12:41548936-41548938 (+)	474,848 bp
Tssr113354	Chr12:41779201-41779204 (+)	705,114 bp
Tssr113355	Chr12:41872587-41872591 (+)	798,500 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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