Cox4i2 MGI Mouse Gene Detail - MGI:2135755 - cytochrome c oxidase subunit 4I2

Symbol

Cox4i2
Name

cytochrome c oxidase subunit 4I2
Synonyms

Cox4b, Cox IV-2

Feature Type

protein coding gene
IDs

MGI:2135755
NCBI Gene: 84682
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:152596093-152606957 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 75.41 cM, cytoband H2
Mapping Data

1 experiment

SNPs within 2kb

391 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2135755	protein coding gene	Chr2:152596093-152606957 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026677	protein coding gene	Chr2:157333330-157344228 (+)
A/J	MGP_AJ_G0026643	protein coding gene	Chr2:151049652-151060545 (+)
AKR/J	MGP_AKRJ_G0026613	protein coding gene	Chr2:155451839-155463964 (+)
BALB/cJ	MGP_BALBcJ_G0026652	protein coding gene	Chr2:151358982-151369833 (+)
C3H/HeJ	MGP_C3HHeJ_G0026395	protein coding gene	Chr2:155838523-155850164 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027101	protein coding gene	Chr2:161896848-161907883 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024472	protein coding gene	Chr2:144640190-144651926 (+)
CAST/EiJ	MGP_CASTEiJ_G0025856	protein coding gene	Chr2:156091137-156103301 (+)
CBA/J	MGP_CBAJ_G0026373	protein coding gene	Chr2:167857586-167868442 (+)
DBA/2J	MGP_DBA2J_G0026509	protein coding gene	Chr2:150262184-150272988 (+)
FVB/NJ	MGP_FVBNJ_G0026475	protein coding gene	Chr2:148719464-148730257 (+)
LP/J	MGP_LPJ_G0026613	protein coding gene	Chr2:157488947-157499818 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026496	protein coding gene	Chr2:171937592-171948479 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027157	protein coding gene	Chr2:155354542-155365402 (+)
PWK/PhJ	MGP_PWKPhJ_G0025590	protein coding gene	Chr2:149782717-149794242 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025393	protein coding gene	Chr2:154192082-154202963 (+)
WSB/EiJ	MGP_WSBEiJ_G0025926	protein coding gene	Chr2:156259565-156270384 (+)

Human Ortholog

COX4I2, cytochrome c oxidase subunit 4I2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COX4I2, cytochrome c oxidase subunit 4I2
Synonyms

COX4, COX4-2, COX4B, COX4L2, COXIV-2, dJ857M17.2
Links

HGNC:16232

NCBI Gene ID: 84701

neXtProt AC: NX_Q96KJ9

UniProt: Q96KJ9
Chr Location

20q11.21; chr20:31637912-31645006 (+) GRCh38

MGI Vertebrate Homology

Cox4i2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: COX4I2
Gene Tree

Cox4i2

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

10
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Cox4i2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display lung inflammation and decreased airway responsiveness. Females show decreased lean body mass and improved glucose tolerance.

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All GO Annotations

11
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

805
Tissues

98
cDNA Data

10
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cox4i2

ZFIN cox4i2

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All Sequences

29
RefSeq

2
UniProt

1
CCDS

CCDS16898.1

Ensembl

ENSMUSG00000009876 (Evidence)
NCBI Gene

84682

			Length	Strain/Species	Flank
genomic	84682	NCBI Gene Model \| MGI Sequence Detail	10865	C57BL/6J	± kb
transcript	NM_053091	RefSeq \| MGI Sequence Detail	727	C57BL/6
polypeptide	Q91W29	UniProt \| EBI \| MGI Sequence Detail	172	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000005777 cytochrome c oxidase subunit 4 isoform 2, mitochondrial

(term hierarchy)
InterPro Domains

IPR013288 Cytochrome c oxidase subunit IV

IPR004203 Cytochrome c oxidase subunit IV family

IPR036639 Cytochrome c oxidase subunit IV superfamily

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All nucleic 12

cDNA 10

Primer pair 2

Microarray probesets 2

Summaries

All 49

Developmental Gene Expression 10

Gene Ontology 10

Phenotypes 13
Earliest

J:304 STEIN KF, et al., Morphology and behavior of Waltzertype mice. J Morphol. 1960 Mar;106:197-203
Latest

J:344566 Zanini F, et al., Hyperoxia prevents the dynamic neonatal increases in lung mesenchymal cell diversity. Sci Rep. 2024 Jan 23;14(1):2033

TSS for Cox4i2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20827	Chr2:152596062-152596073 (+)	-25 bp
Tssr20828	Chr2:152596076-152596106 (+)	-2 bp
Tssr20829	Chr2:152598681-152598710 (+)	2,603 bp
Tssr20830	Chr2:152598916-152598925 (+)	2,828 bp
Tssr20831	Chr2:152598978-152598991 (+)	2,892 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24