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Hspb8 Gene Detail
Summary
  • Symbol
    Hspb8
  • Name
    heat shock protein 8
  • Synonyms
    Cryac, D5Ucla4, E2IG1, H11, H11K, HSP20-like, HSP22
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135756
    NCBI Gene: 80888
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:116546550-116560923 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 56.41 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    446 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135756
 protein coding gene Chr5:116546550-116560923 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029981
 protein coding gene Chr5:119401175-119420217 (-)
A/J MGP_AJ_G0029945
 protein coding gene Chr5:114592953-114607214 (-)
AKR/J MGP_AKRJ_G0029884
 protein coding gene Chr5:118279864-118295944 (-)
BALB/cJ MGP_BALBcJ_G0029956
 protein coding gene Chr5:116002833-116018783 (-)
C3H/HeJ MGP_C3HHeJ_G0029676
 protein coding gene Chr5:118795815-118810396 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030411
 protein coding gene Chr5:123955760-123972022 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027637
 protein coding gene Chr5:109368499-109384031 (-)
CAST/EiJ MGP_CASTEiJ_G0029085
 protein coding gene Chr5:117767790-117787069 (-)
CBA/J MGP_CBAJ_G0029644
 protein coding gene Chr5:128727138-128751834 (-)
DBA/2J MGP_DBA2J_G0029794
 protein coding gene Chr5:114687023-114704904 (-)
FVB/NJ MGP_FVBNJ_G0029750
 protein coding gene Chr5:113523800-113538006 (-)
LP/J MGP_LPJ_G0029882
 protein coding gene Chr5:119922514-119938408 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029781
 protein coding gene Chr5:133015757-133034362 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030452
 protein coding gene Chr5:117784972-117799048 (-)
PWK/PhJ MGP_PWKPhJ_G0028798
 protein coding gene Chr5:113350488-113366517 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028636
 protein coding gene Chr5:115322001-115339270 (-)
WSB/EiJ MGP_WSBEiJ_G0029160
 protein coding gene Chr5:118369606-118391333 (-)



Homology
more
  • Human Ortholog
    HSPB8, heat shock protein family B (small) member 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSPB8, heat shock protein family B (small) member 8
  • Synonyms
    CMT2L, DHMN2, E2IG1, H11, HMN2, HMN2A, HMND2, HSP22, HSPB8-N1, HSPB8-N2
  • Links
    NCBI Gene ID: 26353
    neXtProt AC: NX_Q9UJY1
    UniProt: Q9UJY1

  • Chr Location
    12q24.23; chr12:119171555-119224855 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hspb8 mouse models; 2 with human HSPB8 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 5 alleles in 4 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
When exposed to pressure overload, mice homozygous for a knock-out allele develop less hypertrophy and display ventricular dilation, impaired contractile function, increased myocyte length and accumulation of interstitial collagen, accelerated transitioninto heart failure, and increased mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1055
  • Tissues
    214
  • cDNA Data
    133
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 80888 NCBI Gene Model | MGI Sequence Detail 14374 C57BL/6J ±  kb
    transcript NM_030704 RefSeq | MGI Sequence Detail 1825 ZRU/MplStud  
    polypeptide Q9JK92 UniProt | EBI | MGI Sequence Detail 196 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 136
      cDNA 133
      Primer pair 1
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-7380, MGI:2141037, MGI:2141190, MGI:93475
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 6
      Phenotypes 18
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory