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Cpn1 Gene Detail
Summary
  • Symbol
    Cpn1
  • Name
    carboxypeptidase N, polypeptide 1
  • Synonyms
    0610011F20Rik, 50 kDa, CPN
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135874
    NCBI Gene: 93721
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
  • Candidate for QTL
    6 QTL
Location &
Maps
more
  • Sequence Map
    Chr19:43944746-43974990 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 36.68 cM, cytoband D2
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1183 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135874
 protein coding gene Chr19:43944746-43974995 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025160
 protein coding gene Chr19:43394158-43431747 (-)
A/J MGP_AJ_G0025137
 protein coding gene Chr19:41329290-41361032 (-)
AKR/J MGP_AKRJ_G0025105
 protein coding gene Chr19:42629849-42665007 (-)
BALB/cJ MGP_BALBcJ_G0025131
 protein coding gene Chr19:41374653-41406120 (-)
C3H/HeJ MGP_C3HHeJ_G0024891
 protein coding gene Chr19:42806524-42842636 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025574
 protein coding gene Chr19:44457152-44489827 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022988
 protein coding gene Chr19:40623391-40654510 (-)
CAST/EiJ MGP_CASTEiJ_G0024356
 protein coding gene Chr19:42509310-42541020 (-)
CBA/J MGP_CBAJ_G0024871
 protein coding gene Chr19:46666157-46700615 (-)
DBA/2J MGP_DBA2J_G0025003
 protein coding gene Chr19:41154745-41185285 (-)
FVB/NJ MGP_FVBNJ_G0024964
 protein coding gene Chr19:40905220-40950584 (-)
LP/J MGP_LPJ_G0025089
 protein coding gene Chr19:43354886-43388070 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024995
 protein coding gene Chr19:46196315-46231608 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025632
 protein coding gene Chr19:42720812-42757170 (-)
PWK/PhJ MGP_PWKPhJ_G0024105
 protein coding gene Chr19:41052935-41084706 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023909
 protein coding gene Chr19:41437319-41471032 (-)
WSB/EiJ MGP_WSBEiJ_G0024426
 protein coding gene Chr19:42857443-42889200 (-)



Homology
more
  • Human Ortholog
    CPN1, carboxypeptidase N subunit 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPN1, carboxypeptidase N subunit 1
  • Synonyms
    CPN, SCPN
  • Links
    NCBI Gene ID: 1369
    neXtProt AC: NX_P15169
    UniProt: P15169

  • Chr Location
    10q24.2; chr10:100042193-100081869 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CPN1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are highly susceptible to lethal anaphylactic shock caused by acute complement activation when administered cobra venom factor or C5a complement.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    825
  • Tissues
    43
  • cDNA Data
    53
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 93721 NCBI Gene Model | MGI Sequence Detail 30245 C57BL/6J ±  kb
    transcript NM_030703 RefSeq | MGI Sequence Detail 1792 Not Specified  
    polypeptide Q9JJN5 UniProt | EBI | MGI Sequence Detail 457 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      Genomic 1
      cDNA 53
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1923506
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 11
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:68326 Sato T, et al., Pro-carboxypeptidase R is an acute phase protein in the mouse, whereas carboxypeptidase N is not. J Immunol. 2000 Jul 15;165(2):1053-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory