Entpd7 MGI Mouse Gene Detail - MGI:2135885 - ectonucleoside triphosphate diphosphohydrolase 7

Symbol

Entpd7
Name

ectonucleoside triphosphate diphosphohydrolase 7
Synonyms

1810012B13Rik, 1810020C02Rik, 2810003F23Rik, LALP1, Lysal2

Feature Type

protein coding gene
IDs

MGI:2135885
NCBI Gene: 93685
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr19:43678111-43722136 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 36.67 cM, cytoband D1
Mapping Data

3 experiments

SNPs within 2kb

1391 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2135885	protein coding gene	Chr19:43678111-43722292 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025155	protein coding gene	Chr19:43099850-43151152 (+)
A/J	MGP_AJ_G0025132	protein coding gene	Chr19:41050782-41097353 (+)
AKR/J	MGP_AKRJ_G0025100	protein coding gene	Chr19:42345912-42393247 (+)
BALB/cJ	MGP_BALBcJ_G0025126	protein coding gene	Chr19:41094170-41141334 (+)
C3H/HeJ	MGP_C3HHeJ_G0024886	protein coding gene	Chr19:42522842-42576241 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025569	protein coding gene	Chr19:44170000-44216428 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022983	protein coding gene	Chr19:40348375-40391159 (+)
CAST/EiJ	MGP_CASTEiJ_G0024351	protein coding gene	Chr19:42217617-42264424 (+)
CBA/J	MGP_CBAJ_G0024866	protein coding gene	Chr19:46354415-46410205 (+)
DBA/2J	MGP_DBA2J_G0024998	protein coding gene	Chr19:40878864-40923686 (+)
FVB/NJ	MGP_FVBNJ_G0024959	protein coding gene	Chr19:40633346-40679359 (+)
LP/J	MGP_LPJ_G0025084	protein coding gene	Chr19:43067968-43117146 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024990	protein coding gene	Chr19:45901725-45954386 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025627	protein coding gene	Chr19:42440674-42490713 (+)
PWK/PhJ	MGP_PWKPhJ_G0024100	protein coding gene	Chr19:40776210-40822446 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023904	protein coding gene	Chr19:41150039-41207890 (+)
WSB/EiJ	MGP_WSBEiJ_G0024421	protein coding gene	Chr19:42578078-42626740 (+)

Human Ortholog

ENTPD7, ectonucleoside triphosphate diphosphohydrolase 7

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ENTPD7, ectonucleoside triphosphate diphosphohydrolase 7
Synonyms

LALP1
Links

HGNC:19745

NCBI Gene ID: 57089

neXtProt AC: NX_Q9NQZ7

UniProt: Q9NQZ7
Chr Location

10q24.2; chr10:99659509-99711241 (+) GRCh38

MGI Vertebrate Homology

Entpd7 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ENTPD7
Gene Tree

Entpd7

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Gene trapped

2
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for deletions in this gene have increased Th17 T cell levels in the lamina propria of the small intestine. They show increased resistance to Citrobacter rodentium infection and increased susceptibility to experimental autoimmune encephalomyelitis.

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All GO Annotations

40
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

12

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase entpd7

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All Sequences

48
RefSeq

2
UniProt

1
CCDS

CCDS29835.1

Ensembl

ENSMUSG00000025192 (Evidence)
NCBI Gene

93685

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025192	Ensembl Gene Model \| MGI Sequence Detail	44026	C57BL/6J	± kb
transcript	ENSMUST00000081079	Ensembl \| MGI Sequence Detail	5911	Not Applicable
polypeptide	ENSMUSP00000079864	Ensembl \| MGI Sequence Detail	606	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000007098 ectonucleoside triphosphate diphosphohydrolase 7

(term hierarchy)
EC

3.6.1.15
InterPro Domains

IPR000407 Nucleoside phosphatase GDA1/CD39
GlyGen

Q3TCT4 1 site, 1 N-linked glycan (1 site)

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All nucleic 14

cDNA 14

Microarray probesets 6

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MGI:1916337, MGI:1916350, MGI:1923796

Summaries

All 33

Gene Ontology 8

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:191188 Kusu T, et al., Ecto-Nucleoside Triphosphate Diphosphohydrolase 7 Controls Th17 Cell Responses through Regulation of Luminal ATP in the Small Intestine. J Immunol. 2013 Jan 15;190(2):774-83

TSS for Entpd7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156521	Chr19:43678086-43678097 (+)	-19 bp
Tssr156522	Chr19:43678111-43678134 (+)	12 bp
Tssr156523	Chr19:43678237-43678307 (+)	161 bp
Tssr156524	Chr19:43699856-43699899 (+)	21,767 bp
Tssr156525	Chr19:43719610-43719614 (+)	41,501 bp
Tssr156526	Chr19:43719880-43719900 (+)	41,779 bp
Tssr156527	Chr19:43720217-43720238 (+)	42,117 bp
Tssr156528	Chr19:43720436-43720440 (+)	42,327 bp
Tssr156529	Chr19:43720699-43720703 (+)	42,590 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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