Lcn8 MGI Mouse Gene Detail - MGI:2135945

Symbol

Lcn8
Name

lipocalin 8
Synonyms

9230106L18Rik, EP17, mEP17

Feature Type

protein coding gene
IDs

MGI:2135945
NCBI Gene: 78076
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:25543132-25546229 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 17.67 cM, cytoband A3
Mapping Data

3 experiments

SNPs within 2kb

182 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2135945	protein coding gene	Chr2:25543130-25546229 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025462	protein coding gene	Chr2:23568163-23571260 (+)
A/J	MGP_AJ_G0025439	protein coding gene	Chr2:22645723-22648820 (+)
AKR/J	MGP_AKRJ_G0025409	protein coding gene	Chr2:23408904-23412001 (+)
BALB/cJ	MGP_BALBcJ_G0025435	protein coding gene	Chr2:22763276-22766373 (+)
C3H/HeJ	MGP_C3HHeJ_G0025196	protein coding gene	Chr2:23343297-23346394 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025879	protein coding gene	Chr2:24309674-24312771 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023290	protein coding gene	Chr2:21552009-21555125 (+)
CAST/EiJ	MGP_CASTEiJ_G0024659	protein coding gene	Chr2:23210629-23213723 (+)
CBA/J	MGP_CBAJ_G0025174	protein coding gene	Chr2:25147821-25150918 (+)
DBA/2J	MGP_DBA2J_G0025307	protein coding gene	Chr2:22492974-22496071 (+)
FVB/NJ	MGP_FVBNJ_G0025269	protein coding gene	Chr2:22235807-22238904 (+)
LP/J	MGP_LPJ_G0025393	protein coding gene	Chr2:23502436-23505533 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025300	protein coding gene	Chr2:25331769-25334866 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025938	protein coding gene	Chr2:23367343-23370437 (+)
PWK/PhJ	MGP_PWKPhJ_G0024407	protein coding gene	Chr2:22303629-22306723 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024207	protein coding gene	Chr2:23496719-23499811 (+)
WSB/EiJ	MGP_WSBEiJ_G0024728	protein coding gene	Chr2:23428192-23431285 (+)

Human Ortholog

LCN8, lipocalin 8

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LCN8, lipocalin 8
Synonyms

EP17, LCN5
Links

HGNC:27038

NCBI Gene ID: 138307

neXtProt AC: NX_Q6JVE9

UniProt: Q6JVE9
Chr Location

9q34.3; chr9:136754386-136758543 (-) GRCh38

MGI Vertebrate Homology

Lcn8 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: LCN8
Gene Tree

Lcn8

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

5
Targeted

4
Genomic Mutations

2 involving Lcn8
Incidental Mutations

APF
Find Mice (IMSR)

9 strains or lines available

Mice homozygous for a null allele exhibit teratozoospermia, asthenozoospermia, and spontaneous acrosome reaction without impact on fertility.

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All GO Annotations

3
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

4

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

30
RefSeq

2
UniProt

2
CCDS

CCDS15786.1

Ensembl

ENSMUSG00000036449 (Evidence)
NCBI Gene

78076

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036449	Ensembl Gene Model \| MGI Sequence Detail	3098	C57BL/6J	± kb
transcript	ENSMUST00000038482	Ensembl \| MGI Sequence Detail	651	Not Applicable
polypeptide	ENSMUSP00000043902	Ensembl \| MGI Sequence Detail	175	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009727 epididymal-specific lipocalin-8

(term hierarchy)
InterPro Domains

IPR012674 Calycin

IPR002345 Lipocalin

IPR000566 Lipocalin/cytosolic fatty-acid binding domain
GlyGen

Q924P3 2 sites

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All nucleic 4

cDNA 4

Microarray probesets 2

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MGI:1925326

Summaries

All 26

Gene Ontology 3

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:340906 Sakurai N, et al., CRISPR/Cas9-mediated disruption of lipocalins, Ly6g5b, and Ly6g5c causes male subfertility in mice. Andrology. 2022 Nov 25;

TSS for Lcn8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16746	Chr2:25543006-25543031 (+)	-113 bp
Tssr16747	Chr2:25543123-25543142 (+)	1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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