Prlhr MGI Mouse Gene Detail - MGI:2135956 - prolactin releasing hormone receptor

Symbol

Prlhr
Name

prolactin releasing hormone receptor
Synonyms

Gpr10, GR3, LOC226278, PrRPR

Feature Type

protein coding gene
IDs

MGI:2135956
NCBI Gene: 226278
Alliance

gene page

Sequence Map

Chr19:60455170-60456742 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 56.52 cM
Mapping Data

1 experiment

SNPs within 2kb

82 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2135956	protein coding gene	Chr19:60454079-60457907 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0025292	protein coding gene	Chr19:61039046-61040611 (-)
A/J	MGP_AJ_G0025268	protein coding gene	Chr19:58061503-58063068 (-)
AKR/J	MGP_AKRJ_G0025237	protein coding gene	Chr19:59875726-59877291 (-)
BALB/cJ	MGP_BALBcJ_G0025263	protein coding gene	Chr19:58135412-58136977 (-)
C3H/HeJ	MGP_C3HHeJ_G0025023	protein coding gene	Chr19:60129600-60131165 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025706	protein coding gene	Chr19:62506644-62508215 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023118	protein coding gene	Chr19:56899387-56901026 (-)
CAST/EiJ	MGP_CASTEiJ_G0024488	protein coding gene	Chr19:60217249-60218814 (-)
CBA/J	MGP_CBAJ_G0025003	protein coding gene	Chr19:65550437-65552002 (-)
DBA/2J	MGP_DBA2J_G0025135	protein coding gene	Chr19:57813595-57815160 (-)
FVB/NJ	MGP_FVBNJ_G0025096	protein coding gene	Chr19:57520942-57522507 (-)
LP/J	MGP_LPJ_G0025221	protein coding gene	Chr19:60877858-60879423 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025129	protein coding gene	Chr19:64732485-64734050 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025764	protein coding gene	Chr19:60121286-60122851 (-)
PWK/PhJ	MGP_PWKPhJ_G0024236	protein coding gene	Chr19:57802964-57804529 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0024039	protein coding gene	Chr19:58768474-58770043 (-)
WSB/EiJ	MGP_WSBEiJ_G0024558	protein coding gene	Chr19:60223890-60225455 (-)

Human Ortholog

PRLHR, prolactin releasing hormone receptor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRLHR, prolactin releasing hormone receptor
Synonyms

GPR10, GR3, PrRPR
Links

HGNC:4464

NCBI Gene ID: 2834

neXtProt AC: NX_P49683

UniProt: P49683
Chr Location

10q26.11; chr10:118589997-118595648 (-) GRCh38

MGI Vertebrate Homology

Prlhr stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PRLHR
Gene Tree

Prlhr

Diseases

1 with human PRLHR associations

				Human Disease	Mouse Models
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

21 phenotypes from 3 alleles in 3 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Targeted

3
Incidental Mutations

APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene ate more than normal and became obese as they aged.

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All GO Annotations

18
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prlhr

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All Sequences

30
RefSeq

4
UniProt

1
CCDS

CCDS29940.1

Ensembl

ENSMUSG00000045052 (Evidence)
NCBI Gene

226278

			Length	Strain/Species	Flank
genomic	ENSMUSG00000045052	Ensembl Gene Model \| MGI Sequence Detail	1573	C57BL/6J	± kb
transcript	ENSMUST00000051277	Ensembl \| MGI Sequence Detail	1573	Not Applicable
polypeptide	ENSMUSP00000063114	Ensembl \| MGI Sequence Detail	370	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001546 prolactin-releasing peptide receptor

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR000276 G protein-coupled receptor, rhodopsin-like

IPR001402 Prolactin-releasing peptide receptor
GlyGen

Q6VMN6 2 sites

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All nucleic 5

cDNA 5

Microarray probesets 1

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MGI:2685185

Summaries

All 31

Gene Ontology 8

Phenotypes 8
Earliest

J:90533 Gu W, et al., The prolactin-releasing peptide receptor (GPR10) regulates body weight homeostasis in mice. J Mol Neurosci. 2004;22(1-2):93-103
Latest

J:339803 Talbot F, et al., A rare human variant that disrupts GPR10 signalling causes weight gain in mice. Nat Commun. 2023 Mar 15;14(1):1450

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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