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Gorasp2 Gene Detail
Summary
  • Symbol
    Gorasp2
  • Name
    golgi reassembly stacking protein 2
  • Synonyms
    5730520M13Rik, 9430094F20Rik, ENSMUSG00000075299, GOLPH2, GRASP55, GRS2, p59
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135962
    NCBI Gene: 70231
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:70491520-70522069 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 41.82 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    738 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135962
 protein coding gene Chr2:70491520-70542980 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025815
 protein coding gene Chr2:70717217-70772528 (+)
A/J MGP_AJ_G0025792
 protein coding gene Chr2:67967280-68018602 (+)
AKR/J MGP_AKRJ_G0025761
 protein coding gene Chr2:69813788-69875968 (+)
BALB/cJ MGP_BALBcJ_G0025787
 protein coding gene Chr2:68156780-68207652 (+)
C3H/HeJ MGP_C3HHeJ_G0025547
 protein coding gene Chr2:70038740-70090085 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026234
 protein coding gene Chr2:72842795-72897213 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023637
 protein coding gene Chr2:65201502-65251026 (+)
CAST/EiJ MGP_CASTEiJ_G0025011
 protein coding gene Chr2:70203943-70263197 (+)
CBA/J MGP_CBAJ_G0025527
 protein coding gene Chr2:75545311-75596106 (+)
DBA/2J MGP_DBA2J_G0025658
 protein coding gene Chr2:67601421-67652773 (+)
FVB/NJ MGP_FVBNJ_G0025621
 protein coding gene Chr2:66984268-67035785 (+)
LP/J MGP_LPJ_G0025747
 protein coding gene Chr2:70569228-70621024 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025650
 protein coding gene Chr2:77560389-77615119 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026291
 protein coding gene Chr2:69912771-69964387 (+)
PWK/PhJ MGP_PWKPhJ_G0024752
 protein coding gene Chr2:67461348-67512717 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024559
 protein coding gene Chr2:70117674-70168364 (+)
WSB/EiJ MGP_WSBEiJ_G0025079
 protein coding gene Chr2:70348649-70402141 (+)



Homology
more
  • Human Ortholog
    GORASP2, golgi reassembly stacking protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GORASP2, golgi reassembly stacking protein 2
  • Synonyms
    GOLPH6, GRASP55, GRS2, p59
  • Links
    NCBI Gene ID: 26003
    neXtProt AC: NX_Q9H8Y8
    UniProt: Q9H8Y8

  • Chr Location
    2q31.1; chr2:170928464-170967130 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    2 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit postnatal growth retardation and male infertility associated with impaired spermatogenesis, asthenozoospermia, oligozoospermia, and abnormalities in acrosome formation and Golgi apparatus morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    8
  • cDNA Data
    23
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70231 NCBI Gene Model | MGI Sequence Detail 30550 C57BL/6J ±  kb
    transcript NR_027343 RefSeq | MGI Sequence Detail 2484 C57BL/6  
    polypeptide Q99JX3 UniProt | EBI | MGI Sequence Detail 451 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 30

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1913901, MGI:1917481, MGI:1918930, MGI:1924679, MGI:2139388, MGI:3642751
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:325982 Klaus A, et al., CLASP2 safeguards hematopoietic stem cell properties during mouse and fish development. Cell Rep. 2022 Jun 14;39(11):110957
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory