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Pcdhb12 Gene Detail
Summary
  • Symbol
    Pcdhb12
  • Name
    protocadherin beta 12
  • Synonyms
    Pcdh3, Pcdhb5F, PcdhbL
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136747
    NCBI Gene: 93883
  • Member of
    Pcdhb cluster
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:37568674-37571707 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 19.49 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    303 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2136747
 protein coding gene Chr18:37568674-37571707 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024320
 protein coding gene Chr18:35828417-35831450 (+)
A/J MGP_AJ_G0024288
 protein coding gene Chr18:34608654-34611904 (+)
AKR/J MGP_AKRJ_G0024256
 protein coding gene Chr18:35559863-35562896 (+)
BALB/cJ MGP_BALBcJ_G0024287
 protein coding gene Chr18:34655235-34658268 (+)
C3H/HeJ MGP_C3HHeJ_G0024053
 protein coding gene Chr18:35632329-35635362 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024729
 protein coding gene Chr18:37128465-37131604 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022168
 protein coding gene Chr18:34660507-34663545 (+)
CAST/EiJ MGP_CASTEiJ_G0023529
 protein coding gene Chr18:35594115-35597148 (+)
CBA/J MGP_CBAJ_G0024023
 protein coding gene Chr18:38217690-38220723 (+)
DBA/2J MGP_DBA2J_G0024153
 protein coding gene Chr18:34205371-34208404 (+)
FVB/NJ MGP_FVBNJ_G0024119
 protein coding gene Chr18:33929536-33934723 (+)
LP/J MGP_LPJ_G0024237
 protein coding gene Chr18:35910988-35914021 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024150
 protein coding gene Chr18:39496311-39499916 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024778
 protein coding gene Chr18:35427426-35430459 (+)
PWK/PhJ MGP_PWKPhJ_G0023273
 protein coding gene Chr18:34441905-34445212 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023078
 protein coding gene Chr18:35665334-35668372 (+)
WSB/EiJ MGP_WSBEiJ_G0023591
 protein coding gene Chr18:35319854-35323047 (+)



Homology
more
  • Human Ortholog
    PCDHB5, protocadherin beta 5
  • Vertebrate Orthologs
    13
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PCDHB5, protocadherin beta 5
  • Synonyms
    PCDH-BETA5
  • Links
    NCBI Gene ID: 26167
    neXtProt AC: NX_Q9Y5E4
    UniProt: Q9Y5E4

  • Chr Location
    5q31.3; chr5:141135206-141138615 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    2
  • cDNA Data
    3
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 93883 NCBI Gene Model | MGI Sequence Detail 3034 C57BL/6J ±  kb
transcript NM_053137 RefSeq | MGI Sequence Detail 3034 ZRU/MplStud  
polypeptide NP_444367 RefSeq | MGI Sequence Detail 789 ZRU/MplStud  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR020894 Cadherin conserved site
    IPR032455 Cadherin, cytoplasmic C-terminal domain
    IPR002126 Cadherin-like
    IPR015919 Cadherin-like superfamily
    IPR013164 Cadherin, N-terminal
    IPR050174 Protocadherin/Cadherin-related Cell Adhesion
  • GlyGen
    Q91Y07 2 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 7
    cDNA 5
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-27053, MGI:104690
References
more
  • Summaries
    All 23
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:29362 Sago H, et al., Cloning, expression, and chromosomal localization of a novel cadherin-related protein, protocadherin-3. Genomics. 1995 Oct 10;29(3):631-40
  • Latest
    J:332241 Kobayashi H, et al., Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality. iScience. 2023 Jan 20;26(1):105766
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory