Mrpl33 MGI Mouse Gene Detail - MGI:2137225 - mitochondrial ribosomal protein L33

Symbol

Mrpl33
Name

mitochondrial ribosomal protein L33
Synonyms

0610009M10Rik

Feature Type

protein coding gene
IDs

MGI:2137225
NCBI Gene: 66845
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:31771295-31779988 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 17.27 cM, cytoband B1
Mapping Data

2 experiments

SNPs within 2kb

313 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2137225	protein coding gene	Chr5:31754279-31821728 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029430	protein coding gene	Chr5:29626972-29698506 (+)
A/J	MGP_AJ_G0029396	protein coding gene	Chr5:28670413-28738347 (+)
AKR/J	MGP_AKRJ_G0029346	protein coding gene	Chr5:29821304-29892418 (+)
BALB/cJ	MGP_BALBcJ_G0029407	protein coding gene	Chr5:29201065-29269375 (+)
C3H/HeJ	MGP_C3HHeJ_G0029128	protein coding gene	Chr5:29844094-29913236 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029860	protein coding gene	Chr5:31445999-31513047 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027098	protein coding gene	Chr5:26279424-26353155 (+)
CAST/EiJ	MGP_CASTEiJ_G0028538	protein coding gene	Chr5:28877764-28952733 (+)
CBA/J	MGP_CBAJ_G0029096	protein coding gene	Chr5:32082482-32164021 (+)
DBA/2J	MGP_DBA2J_G0029245	protein coding gene	Chr5:28830900-28898691 (+)
FVB/NJ	MGP_FVBNJ_G0029203	protein coding gene	Chr5:28251479-28319848 (+)
LP/J	MGP_LPJ_G0029330	protein coding gene	Chr5:30073062-30144374 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029232	protein coding gene	Chr5:32910873-32980716 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029894	protein coding gene	Chr5:29319727-29388850 (+)
PWK/PhJ	MGP_PWKPhJ_G0028263	protein coding gene	Chr5:27990364-28060617 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028094	protein coding gene	Chr5:28786762-28858293 (+)
WSB/EiJ	MGP_WSBEiJ_G0028619	protein coding gene	Chr5:29390702-29463306 (+)

Human Ortholog

MRPL33, mitochondrial ribosomal protein L33

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MRPL33, mitochondrial ribosomal protein L33
Synonyms

bL33m, C2orf1, L33mt, MRP-L33, RPL33L
Links

HGNC:14487

NCBI Gene ID: 9553

neXtProt AC: NX_O75394

UniProt: O75394
Chr Location

2p23.2; chr2:27771717-27988087 (+) GRCh38

MGI Vertebrate Homology

Mrpl33 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MRPL33
Gene Tree

Mrpl33

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

2
Endonuclease-mediated

2
Radiation induced

2
Spontaneous

1
Targeted

2
Genomic Mutations

5 involving Mrpl33
Incidental Mutations

APF
Find Mice (IMSR)

115 strains or lines available

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All GO Annotations

10
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

732
Tissues

21
cDNA Data

12
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mrpl33

ZFIN mrpl33

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All Sequences

52
RefSeq

2
UniProt

2
CCDS

CCDS39056.1

Ensembl

ENSMUSG00000106918 (Evidence)
NCBI Gene

66845

			Length	Strain/Species	Flank
genomic	66845	NCBI Gene Model \| MGI Sequence Detail	8694	C57BL/6J	± kb
transcript	NM_025796	RefSeq \| MGI Sequence Detail	484	C57BL/6
polypeptide	Q9CQP0	UniProt \| EBI \| MGI Sequence Detail	65	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010593 large ribosomal subunit protein bL33m

(term hierarchy)
InterPro Domains

IPR001705 Large ribosomal subunit protein bL33

IPR038584 Large ribosomal subunit protein bL33 superfamily

IPR052008 Mitochondrial ribosomal protein bL33

IPR011332 Zinc-binding ribosomal protein

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All nucleic 14

cDNA 13

Primer pair 1

Microarray probesets 5

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MGI:1914095

Summaries

All 58

Developmental Gene Expression 3

Diseases 1

Gene Ontology 9

Phenotypes 28
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mrpl33:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45722	Chr5:31771285-31771288 (+)	-8 bp
Tssr45723	Chr5:31771293-31771323 (+)	13 bp
Tssr45724	Chr5:31771334-31771345 (+)	45 bp
Tssr45725	Chr5:31771364-31771374 (+)	74 bp
Tssr1450	Chr5:31772221-31772257 (+)	944 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24