Med15 MGI Mouse Gene Detail - MGI:2137379 - mediator complex subunit 15

Symbol

Med15
Name

mediator complex subunit 15
Synonyms

A230074L19Rik, Pcqap

Feature Type

protein coding gene
IDs

MGI:2137379
NCBI Gene: 94112
Alliance

gene page
Transcription Start Sites

13 TSS

Sequence Map

Chr16:17469072-17540811 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 10.94 cM
Mapping Data

3 experiments

SNPs within 2kb

1056 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2137379	protein coding gene	Chr16:17469072-17550755 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022589	protein coding gene	Chr16:14821901-14896132 (-)
A/J	MGP_AJ_G0022550	protein coding gene	Chr16:14085368-14156063 (-)
AKR/J	MGP_AKRJ_G0022527	protein coding gene	Chr16:14630354-14701523 (-)
BALB/cJ	MGP_BALBcJ_G0022553	protein coding gene	Chr16:14239707-14311348 (-)
C3H/HeJ	MGP_C3HHeJ_G0022320	protein coding gene	Chr16:14781785-14855400 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023004	protein coding gene	Chr16:15052879-15130090 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020524	protein coding gene	Chr16:14139068-14214326 (-)
CAST/EiJ	MGP_CASTEiJ_G0021848	protein coding gene	Chr16:14688083-14774233 (-)
CBA/J	MGP_CBAJ_G0022291	protein coding gene	Chr16:15724079-15799461 (-)
DBA/2J	MGP_DBA2J_G0022421	protein coding gene	Chr16:13999779-14071158 (-)
FVB/NJ	MGP_FVBNJ_G0022397	protein coding gene	Chr16:14040428-14113463 (-)
LP/J	MGP_LPJ_G0022488	protein coding gene	Chr16:14575292-14648442 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022418	protein coding gene	Chr16:15414747-15491386 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023015	protein coding gene	Chr16:14578718-14653533 (-)
PWK/PhJ	MGP_PWKPhJ_G0021591	protein coding gene	Chr16:14256126-14329211 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021419	protein coding gene	Chr16:14550343-14624686 (-)
WSB/EiJ	MGP_WSBEiJ_G0021895	protein coding gene	Chr16:14566753-14639551 (-)

Human Ortholog

MED15, mediator complex subunit 15

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MED15, mediator complex subunit 15
Synonyms

ARC105, CAG7A, CTG7A, PCQAP, TIG-1, TIG1, TNRC7
Links

HGNC:14248

NCBI Gene ID: 51586

neXtProt AC: NX_Q96RN5

UniProt: Q96RN5
Chr Location

22q11.21; chr22:20495913-20587632 (+) GRCh38

MGI Vertebrate Homology

Med15 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MED15
Gene Tree

Med15

Diseases

1 with human MED15 associations

				Human Disease	Mouse Models
				schizophrenia IDs schizophrenia DOID:5419 DOID:14734 ICD10CM:F20 ICD9CM:295 ICD9CM:295.8 ICD9CM:295.80 ICD9CM:295.9 ICD9CM:295.90 MESH:D012559 NCI:C3362 OMIM:181500 UMLS_CUI:C0036341

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

10 phenotype references

All Mutations and Alleles

25
Endonuclease-mediated

2
Gene trapped

21
Targeted

2
Genomic Mutations

1 involving Med15
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

50 strains or lines available

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All GO Annotations

13
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

861
Tissues

145
cDNA Data

85
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase med15

ZFIN med15

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All Sequences

121
RefSeq

41
UniProt

14
CCDS

CCDS37273.1, CCDS37274.1, CCDS88891.1, CCDS88892.1

Ensembl

ENSMUSG00000012114 (Evidence)
NCBI Gene

94112

			Length	Strain/Species	Flank
genomic	94112	NCBI Gene Model \| MGI Sequence Detail	71740	C57BL/6J	± kb
transcript	NM_001285884	RefSeq \| MGI Sequence Detail	3417	ZRU/MplStud
polypeptide	Q924H2	UniProt \| EBI \| MGI Sequence Detail	789	Not Applicable

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UniProt

14 Sequences
Protein Ontology

PR:000010287 mediator of RNA polymerase II transcription subunit 15

(term hierarchy)
PDB

6W1S, 8T1I
InterPro Domains

IPR048385 ARC105/Med15 mediator subunit, central domain

IPR048386 ARC105/Med15 mediator subunit, C-terminal domain

IPR036529 Coactivator CBP, KIX domain superfamily

IPR019087 Mediator of RNA polymerase II transcription subunit 15, N-terminal
GlyGen

Q924H2 1 site, 1 O-linked glycan (1 site)

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All nucleic 89

cDNA 87

Primer pair 2

Microarray probesets 5

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MGI:2146647, MGI:2442332

Summaries

All 44

Developmental Gene Expression 5

Diseases 1

Gene Ontology 8

Phenotypes 10
Earliest

J:70224 Berti L, et al., Isolation and characterization of a novel gene from the digeorge chromosomal region that encodes for a mediator subunit. Genomics. 2001 Jun 15;74(3):320-32
Latest

J:347774 Kolonay DW, et al., Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease. Front Cell Dev Biol. 2024;12:1331563

TSS for Med15:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr140211	Chr16:17540805-17540818 (-)	-1 bp
Tssr140210	Chr16:17540743-17540800 (-)	39 bp
Tssr140209	Chr16:17540332-17540372 (-)	459 bp
Tssr140208	Chr16:17540316-17540330 (-)	488 bp
Tssr140207	Chr16:17522264-17522273 (-)	18,542 bp
Tssr140206	Chr16:17522252-17522263 (-)	18,553 bp
Tssr140205	Chr16:17509491-17509495 (-)	31,318 bp
Tssr140204	Chr16:17498476-17498495 (-)	42,325 bp
Tssr140203	Chr16:17491176-17491199 (-)	49,623 bp
Tssr140202	Chr16:17491049-17491148 (-)	49,712 bp
Tssr140201	Chr16:17481307-17481339 (-)	59,488 bp
Tssr140200	Chr16:17473417-17473444 (-)	67,380 bp
Tssr140199	Chr16:17472543-17472550 (-)	68,264 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24