Slc24a3 MGI Mouse Gene Detail - MGI:2137513 - solute carrier family 24 (sodium/potassium/calcium exchanger), member 3

Symbol

Slc24a3
Name

solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Synonyms

NCKX3

Feature Type

protein coding gene
IDs

MGI:2137513
NCBI Gene: 94249
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:145009695-145484086 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 71.08 cM, cytoband H1
Mapping Data

1 experiment

SNPs within 2kb

12023 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2137513	protein coding gene	Chr2:145009674-145484086 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026593	protein coding gene	Chr2:149283195-149770183 (+)
A/J	MGP_AJ_G0026557	protein coding gene	Chr2:143256749-143726364 (+)
AKR/J	MGP_AKRJ_G0026531	protein coding gene	Chr2:147386409-147869376 (+)
BALB/cJ	MGP_BALBcJ_G0026569	protein coding gene	Chr2:143685609-144159429 (+)
C3H/HeJ	MGP_C3HHeJ_G0026312	protein coding gene	Chr2:147911173-148389992 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027014	protein coding gene	Chr2:153747201-154245757 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024391	protein coding gene	Chr2:137402786-137868259 (+)
CAST/EiJ	MGP_CASTEiJ_G0025773	protein coding gene	Chr2:148236212-148723187 (+)
CBA/J	MGP_CBAJ_G0026292	protein coding gene	Chr2:159311985-159809937 (+)
DBA/2J	MGP_DBA2J_G0026426	protein coding gene	Chr2:142524645-143018780 (+)
FVB/NJ	MGP_FVBNJ_G0026390	protein coding gene	Chr2:141093243-141565915 (+)
LP/J	MGP_LPJ_G0026530	protein coding gene	Chr2:149464578-149964426 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026410	protein coding gene	Chr2:163548162-164037724 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027069	protein coding gene	Chr2:147376153-147876563 (+)
PWK/PhJ	MGP_PWKPhJ_G0025508	protein coding gene	Chr2:142191897-142689105 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025309	protein coding gene	Chr2:146392681-146880822 (+)
WSB/EiJ	MGP_WSBEiJ_G0025846	protein coding gene	Chr2:148349115-148830931 (+)

Human Ortholog

SLC24A3, solute carrier family 24 member 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC24A3, solute carrier family 24 member 3
Synonyms

NCKX3
Links

HGNC:10977

NCBI Gene ID: 57419

neXtProt AC: NX_Q9HC58

UniProt: Q9HC58
Chr Location

20p11.23

MGI Vertebrate Homology

Slc24a3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC24A3
Gene Tree

Slc24a3

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Phenotype Summary

20 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

5
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Slc24a3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Null mice show reduced bone mineral content, density and bone strength, thinner compact bone, increased parathyroid hormone level, shorter duodenum villus length, increased severity of induced colitis, increased depression-related behavior, and motor learning and sociability deficits.

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All GO Annotations

26
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

903
Tissues

29
cDNA Data

24
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc24a3

ZFIN slc24a3

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All Sequences

39
RefSeq

4
UniProt

2
CCDS

CCDS38256.1, CCDS89560.1

Ensembl

ENSMUSG00000063873 (Evidence)
NCBI Gene

94249

			Length	Strain/Species	Flank
genomic	94249	NCBI Gene Model \| MGI Sequence Detail	474392	C57BL/6J	± kb
transcript	NM_001356497	RefSeq \| MGI Sequence Detail	4027	C57BL/6
polypeptide	Q99PD7	UniProt \| EBI \| MGI Sequence Detail	645	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000015000 sodium/potassium/calcium exchanger 3

(term hierarchy)
InterPro Domains

IPR044880 NCX, central ion-binding domain superfamily

IPR004837 Sodium/calcium exchanger membrane region

IPR004481 Sodium/potassium/calcium exchanger
GlyGen

Q99PD7 3 sites, 3 N-linked glycans (3 sites)

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All nucleic 26

cDNA 24

Primer pair 2

Microarray probesets 4

Summaries

All 40

Developmental Gene Expression 5

Gene Ontology 9

Phenotypes 12
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Slc24a3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20554	Chr2:145009425-145009440 (+)	-262 bp
Tssr20555	Chr2:145009626-145009693 (+)	-35 bp
Tssr20556	Chr2:145009766-145009820 (+)	98 bp
Tssr20557	Chr2:145009824-145009902 (+)	168 bp
Tssr20558	Chr2:145028329-145028334 (+)	18,637 bp
Tssr20559	Chr2:145302161-145302166 (+)	292,469 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24