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Rcc1l Gene Detail
Summary
  • Symbol
    Rcc1l
  • Name
    reculator of chromosome condensation 1 like
  • Synonyms
    5730496C04Rik, Wbscr16
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137600
    NCBI Gene: 94254
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:134176893-134205613 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 74.42 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    875 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137600
 protein coding gene Chr5:134176893-134207963 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030152
 protein coding gene Chr5:138508785-138548223 (-)
A/J MGP_AJ_G0030120
 protein coding gene Chr5:132649206-132677842 (-)
AKR/J MGP_AKRJ_G0030053
 protein coding gene Chr5:136927152-136957384 (-)
BALB/cJ MGP_BALBcJ_G0030130
 protein coding gene Chr5:133978059-134009670 (-)
C3H/HeJ MGP_C3HHeJ_G0029846
 protein coding gene Chr5:137475253-137507882 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030583
 protein coding gene Chr5:143735152-143774185 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027807
 protein coding gene Chr5:126923007-126952636 (-)
CAST/EiJ MGP_CASTEiJ_G0029255
 protein coding gene Chr5:136916781-136949329 (-)
CBA/J MGP_CBAJ_G0029816
 protein coding gene Chr5:149330274-149369840 (-)
DBA/2J MGP_DBA2J_G0029967
 protein coding gene Chr5:132552513-132581849 (-)
FVB/NJ MGP_FVBNJ_G0029923
 protein coding gene Chr5:131676657-131707693 (-)
LP/J MGP_LPJ_G0030055
 protein coding gene Chr5:138998744-139028976 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029954
 protein coding gene Chr5:152448929-152482353 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030623
 protein coding gene Chr5:136664309-136697023 (-)
PWK/PhJ MGP_PWKPhJ_G0028970
 protein coding gene Chr5:131562871-131592044 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028805
 protein coding gene Chr5:134230236-134262959 (-)
WSB/EiJ MGP_WSBEiJ_G0029329
 protein coding gene Chr5:137396205-137432470 (-)



Homology
more
  • Human Ortholog
    RCC1L, RCC1 like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RCC1L, RCC1 like
  • Synonyms
    WBSCR16
  • Links
    NCBI Gene ID: 81554
    neXtProt AC: NX_Q96I51
    UniProt: Q96I51

  • Chr Location
    7q11.23; chr7:75027119-75074228 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RCC1L associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit early embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    8
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061979 Ensembl Gene Model | MGI Sequence Detail 28721 C57BL/6J ±  kb
transcript ENSMUST00000076228 Ensembl | MGI Sequence Detail 2321 Not Applicable  
polypeptide ENSMUSP00000075581 Ensembl | MGI Sequence Detail 461 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000017380 RCC1-like G exchanging factor-like protein
    (term hierarchy)
  • InterPro Domains
    IPR053035 Mitochondrial GEF domain-containing protein
    IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
    IPR000408 Regulator of chromosome condensation, RCC1
Molecular
Reagents
less
  • All nucleic 11
    Genomic 2
    cDNA 8
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:2141050
References
more
  • Summaries
    All 39
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory