Kmo MGI Mouse Gene Detail - MGI:2138151 - kynurenine 3-monooxygenase

Symbol

Kmo
Name

kynurenine 3-monooxygenase
Synonyms

kynurenine 3-hydroxylase

Feature Type

protein coding gene
IDs

MGI:2138151
NCBI Gene: 98256
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr1:175459759-175488419 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 81.60 cM
Mapping Data

1 experiment

SNPs within 2kb

1175 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2138151	protein coding gene	Chr1:175447947-175489682 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016837	protein coding gene	Chr1:181720335-181763560 (+)
A/J	MGP_AJ_G0016816	protein coding gene	Chr1:174390667-174439754 (+)
AKR/J	MGP_AKRJ_G0016782	protein coding gene	Chr1:179607810-179652384 (+)
BALB/cJ	MGP_BALBcJ_G0016774	protein coding gene	Chr1:174931547-174973195 (+)
C3H/HeJ	MGP_C3HHeJ_G0016599	protein coding gene	Chr1:180218505-180261357 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017239	protein coding gene	Chr1:187717090-187763763 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014944	protein coding gene	Chr1:165710723-165753442 (+)
CAST/EiJ	MGP_CASTEiJ_G0016180	protein coding gene	Chr1:179581237-179628767 (+)
CBA/J	MGP_CBAJ_G0016573	protein coding gene	Chr1:194576519-194617816 (+)
DBA/2J	MGP_DBA2J_G0016678	protein coding gene	Chr1:173251525-173293212 (+)
FVB/NJ	MGP_FVBNJ_G0016675	protein coding gene	Chr1:171376699-171418545 (+)
LP/J	MGP_LPJ_G0016754	protein coding gene	Chr1:182915344-182957148 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016707	protein coding gene	Chr1:201815686-201858785 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017274	protein coding gene	Chr1:179381716-179425362 (+)
PWK/PhJ	MGP_PWKPhJ_G0015967	protein coding gene	Chr1:172340370-172382684 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015744	protein coding gene	Chr1:178419380-178460997 (+)
WSB/EiJ	MGP_WSBEiJ_G0016242	protein coding gene	Chr1:179578989-179622569 (+)

Human Ortholog

KMO, kynurenine 3-monooxygenase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KMO, kynurenine 3-monooxygenase
Synonyms

dJ317G22.1
Links

HGNC:6381

NCBI Gene ID: 8564

neXtProt AC: NX_O15229

UniProt: O15229
Chr Location

1q43; chr1:241532134-241595642 (+) GRCh38

MGI Vertebrate Homology

Kmo stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KMO
Gene Tree

Kmo

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Phenotype Summary

6 phenotypes from 3 alleles in 3 genetic backgrounds
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Endonuclease-mediated

2
Targeted

6
Genomic Mutations

2 involving Kmo
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele lack kynurenine 3-monooxygenase activity and altered levels of several tryptophan metabolites. Mice homozygous for another null allele exhibit increased LPS-induced depressive behaviors and altered kynurenine metabolism.

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All GO Annotations

41
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

810
Tissues

98
cDNA Data

10
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kmo

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All Sequences

43
RefSeq

2
UniProt

2
CCDS

CCDS15548.1

Ensembl

ENSMUSG00000039783 (Evidence)
NCBI Gene

98256

			Length	Strain/Species	Flank
genomic	98256	NCBI Gene Model \| MGI Sequence Detail	28661	C57BL/6J	± kb
transcript	NM_133809	RefSeq \| MGI Sequence Detail	2512	FVB/N
polypeptide	Q91WN4	UniProt \| EBI \| MGI Sequence Detail	479	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009427 kynurenine 3-monooxygenase

(term hierarchy)
EC

1.14.13.9
InterPro Domains

IPR002938 FAD-binding domain

IPR036188 FAD/NAD(P)-binding domain superfamily

IPR027545 Kynurenine 3-monooxygenase
GlyGen

Q91WN4 1 site, 1 O-linked glycan (1 site)

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All nucleic 10

cDNA 10

Microarray probesets 3

Summaries

All 54

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 25
Earliest

J:86816 Mootha VK, et al., Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell. 2003 Nov 26;115(5):629-40
Latest

J:339010 Hayes AJ, et al., Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis. Cell Rep. 2023 Jul 19;42(8):112763

TSS for Kmo:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10313	Chr1:175459534-175459544 (+)	-220 bp
Tssr10314	Chr1:175459562-175459567 (+)	-194 bp
Tssr10315	Chr1:175459581-175459590 (+)	-173 bp
Tssr10316	Chr1:175459610-175459623 (+)	-142 bp
Tssr10317	Chr1:175459630-175459660 (+)	-114 bp
Tssr10318	Chr1:175459662-175459667 (+)	-94 bp
Tssr10319	Chr1:175459670-175459677 (+)	-85 bp
Tssr10320	Chr1:175459686-175459699 (+)	-66 bp
Tssr10321	Chr1:175459707-175459717 (+)	-47 bp
Tssr10322	Chr1:175459721-175459726 (+)	-35 bp
Tssr10323	Chr1:175459735-175459751 (+)	-16 bp
Tssr10324	Chr1:175465445-175465461 (+)	5,694 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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