Sulf1 MGI Mouse Gene Detail - MGI:2138563

Symbol

Sulf1
Name

sulfatase 1

Feature Type

protein coding gene
IDs

MGI:2138563
NCBI Gene: 240725
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr1:12762501-12931416 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 3.35 cM
Mapping Data

1 experiment

SNPs within 2kb

4904 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2138563	protein coding gene	Chr1:12762421-12946090 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015838	protein coding gene	Chr1:10019307-10194147 (+)
A/J	MGP_AJ_G0015820	protein coding gene	Chr1:10026818-10194299 (+)
AKR/J	MGP_AKRJ_G0015779	protein coding gene	Chr1:9910435-10093190 (+)
BALB/cJ	MGP_BALBcJ_G0015776	protein coding gene	Chr1:9720581-9894082 (+)
C3H/HeJ	MGP_C3HHeJ_G0015610	protein coding gene	Chr1:9893801-10073728 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016230	protein coding gene	Chr1:10518255-10698221 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0013951	protein coding gene	Chr1:8660993-8826967 (+)
CAST/EiJ	MGP_CASTEiJ_G0015190	protein coding gene	Chr1:10060131-10235005 (+)
CBA/J	MGP_CBAJ_G0015583	protein coding gene	Chr1:10733804-10917386 (+)
DBA/2J	MGP_DBA2J_G0015682	protein coding gene	Chr1:9625440-9794241 (+)
FVB/NJ	MGP_FVBNJ_G0015687	protein coding gene	Chr1:9450541-9624595 (+)
LP/J	MGP_LPJ_G0015754	protein coding gene	Chr1:10212925-10391250 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015706	protein coding gene	Chr1:11463888-11644180 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016277	protein coding gene	Chr1:9829297-10006620 (+)
PWK/PhJ	MGP_PWKPhJ_G0014974	protein coding gene	Chr1:9437032-9607661 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014755	protein coding gene	Chr1:10049750-10226956 (+)
WSB/EiJ	MGP_WSBEiJ_G0015254	protein coding gene	Chr1:9840727-10023120 (+)

Human Ortholog

SULF1, sulfatase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SULF1, sulfatase 1
Synonyms

SULF-1
Links

HGNC:20391

NCBI Gene ID: 23213

neXtProt AC: NX_Q8IWU6

UniProt: Q8IWU6
Chr Location

8q13.2-q13.3; chr8:69466624-69660915 (+) GRCh38

MGI Vertebrate Homology

Sulf1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SULF1
Protein SuperFamily

Sulf1
Gene Tree

Sulf1

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Phenotype Summary

8 phenotypes from 5 alleles in 5 genetic backgrounds
52 phenotypes from multigenic genotypes
3 images
39 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

89
Endonuclease-mediated

2
Gene trapped

78
Targeted

9
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

112 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display a slight increase in mortality early in life.

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All GO Annotations

66
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

947
Tissues

184
cDNA Data

165
Literature Summary

28

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sulf1

ZFIN sulf1

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All Sequences

78
RefSeq

20
UniProt

5
CCDS

CCDS14820.1

Ensembl

ENSMUSG00000016918 (Evidence)
NCBI Gene

240725

			Length	Strain/Species	Flank
genomic	ENSMUSG00000016918	Ensembl Gene Model \| MGI Sequence Detail	168916	C57BL/6J	± kb
transcript	ENSMUST00000177608	Ensembl \| MGI Sequence Detail	5598	Not Applicable
polypeptide	ENSMUSP00000137523	Ensembl \| MGI Sequence Detail	870	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000015816 extracellular sulfatase Sulf-1

(term hierarchy)
EC

3.1.6.1, 3.1.6.14
InterPro Domains

IPR017850 Alkaline-phosphatase-like, core domain superfamily

IPR014615 Extracellular sulfatase

IPR024609 Extracellular sulfatase, C-terminal

IPR024607 Sulfatase, conserved site

IPR000917 Sulfatase, N-terminal
GlyGen

Q8K007 11 sites, 3 N-linked glycans (5 sites)

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All nucleic 178

cDNA 166

Primer pair 9

Other 3

Microarray probesets 3

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MGI:2138273

Summaries

All 88

Developmental Gene Expression 28

Gene Ontology 15

Phenotypes 39
Earliest

J:80928 Morimoto-Tomita M, et al., Cloning and Characterization of Two Extracellular Heparin-degrading Endosulfatases in Mice and Humans. J Biol Chem. 2002 Dec 20;277(51):49175-85
Latest

J:342037 Tsuji Y, et al., Diffusion magnetic resonance tractography-based evaluation of commissural fiber abnormalities in a heparan sulfate endosulfatase-deficient mouse brain. Magn Reson Imaging. 2022 May;88:123-131

TSS for Sulf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr5948	Chr1:12762582-12762589 (+)	85 bp
Tssr5949	Chr1:12762629-12762643 (+)	135 bp
Tssr5950	Chr1:12762657-12762709 (+)	182 bp
Tssr5951	Chr1:12762713-12762763 (+)	237 bp
Tssr5952	Chr1:12762766-12762778 (+)	271 bp
Tssr5953	Chr1:12762793-12762809 (+)	300 bp
Tssr5954	Chr1:12788720-12788737 (+)	26,228 bp
Tssr5955	Chr1:12788897-12788977 (+)	26,436 bp
Tssr5956	Chr1:12795597-12795598 (+)	33,097 bp
Tssr5957	Chr1:12814999-12815006 (+)	52,502 bp
Tssr5958	Chr1:12842358-12842361 (+)	79,859 bp
Tssr5959	Chr1:12878072-12878111 (+)	115,591 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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