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Ldlrad3 Gene Detail
Summary
  • Symbol
    Ldlrad3
  • Name
    low density lipoprotein receptor class A domain containing 3
  • Synonyms
    Lrad3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138856
    NCBI Gene: 241576
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:101780548-102016730 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 54.11 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    7318 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138856
 protein coding gene Chr2:101780546-102016805 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026194
 protein coding gene Chr2:103833689-104082350 (-)
A/J MGP_AJ_G0026155
 protein coding gene Chr2:99556918-99808468 (-)
AKR/J MGP_AKRJ_G0026136
 protein coding gene Chr2:102270018-102508789 (-)
BALB/cJ MGP_BALBcJ_G0026164
 protein coding gene Chr2:99855351-100091320 (-)
C3H/HeJ MGP_C3HHeJ_G0025915
 protein coding gene Chr2:102637144-102877255 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026615
 protein coding gene Chr2:107346126-107592803 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024006
 protein coding gene Chr2:95263000-95498332 (-)
CAST/EiJ MGP_CASTEiJ_G0025380
 protein coding gene Chr2:103053101-103301848 (-)
CBA/J MGP_CBAJ_G0025893
 protein coding gene Chr2:111054551-111300718 (-)
DBA/2J MGP_DBA2J_G0026029
 protein coding gene Chr2:99143220-99380832 (-)
FVB/NJ MGP_FVBNJ_G0025992
 protein coding gene Chr2:98137956-98377374 (-)
LP/J MGP_LPJ_G0026133
 protein coding gene Chr2:104003903-104247580 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026018
 protein coding gene Chr2:115031084-115277720 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026669
 protein coding gene Chr2:102479036-102723785 (-)
PWK/PhJ MGP_PWKPhJ_G0025115
 protein coding gene Chr2:98616125-98859005 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024916
 protein coding gene Chr2:101687214-101932186 (-)
WSB/EiJ MGP_WSBEiJ_G0025447
 protein coding gene Chr2:103181703-103423049 (-)



Homology
more
  • Human Ortholog
    LDLRAD3, low density lipoprotein receptor class A domain containing 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LDLRAD3, low density lipoprotein receptor class A domain containing 3
  • Synonyms
    LRAD3
  • Links
    NCBI Gene ID: 143458
    neXtProt AC: NX_Q86YD5
    UniProt: Q86YD5

  • Chr Location
    11p13; chr11:35943981-36232136 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    114
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Gene trapped
    107
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    4 involving Ldlrad3
  • Incidental Mutations
    CvDC
  • Find Mice (IMSR)
    42 strains or lines available
Homozygous knockout results in resistance to Venezuelan equine encephalitis virus (VEEV) infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    8
  • cDNA Data
    12
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048058 Ensembl Gene Model | MGI Sequence Detail 236183 C57BL/6J ±  kb
transcript ENSMUST00000058790 Ensembl | MGI Sequence Detail 3833 Not Applicable  
polypeptide ENSMUSP00000054134 Ensembl | MGI Sequence Detail 345 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000032554 low-density lipoprotein receptor class A domain-containing protein 3
    (term hierarchy)
  • PDB
    7N1H
  • InterPro Domains
    IPR036055 LDL receptor-like superfamily
    IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
    IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
    IPR050685 Low-density lipoprotein receptor
  • GlyGen
    A2AR95 1 site
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 3
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 15
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:339954 Kafai NM, et al., Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice. Cell Rep. 2023 Aug 29;42(8):112946
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory