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Usp6nl Gene Detail
Summary
  • Symbol
    Usp6nl
  • Name
    USP6 N-terminal like
  • Synonyms
    mKIAA0019, TRE2NL
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138893
    NCBI Gene: 98910
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:6327478-6451201 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 3.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3399 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138893
 protein coding gene Chr2:6327444-6453107 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025331
 protein coding gene Chr2:3478703-3612692 (+)
A/J MGP_AJ_G0025308
 protein coding gene Chr2:3312660-3437071 (+)
AKR/J MGP_AKRJ_G0025276
 protein coding gene Chr2:3425698-3553194 (+)
BALB/cJ MGP_BALBcJ_G0025304
 protein coding gene Chr2:3302787-3426919 (+)
C3H/HeJ MGP_C3HHeJ_G0025064
 protein coding gene Chr2:3358152-3488476 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025746
 protein coding gene Chr2:3585586-3713399 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023160
 protein coding gene Chr2:3113660-3236623 (+)
CAST/EiJ MGP_CASTEiJ_G0024527
 protein coding gene Chr2:3425855-3562728 (+)
CBA/J MGP_CBAJ_G0025043
 protein coding gene Chr2:3746517-3880764 (+)
DBA/2J MGP_DBA2J_G0025175
 protein coding gene Chr2:3261317-3386919 (+)
FVB/NJ MGP_FVBNJ_G0025137
 protein coding gene Chr2:3264714-3392293 (+)
LP/J MGP_LPJ_G0025261
 protein coding gene Chr2:3424126-3553774 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025169
 protein coding gene Chr2:3549261-3684818 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025804
 protein coding gene Chr2:3416605-3540357 (+)
PWK/PhJ MGP_PWKPhJ_G0024278
 protein coding gene Chr2:3255085-3382715 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024078
 protein coding gene Chr2:3392670-3527837 (+)
WSB/EiJ MGP_WSBEiJ_G0024597
 protein coding gene Chr2:3458763-3587471 (+)



Homology
more
  • Human Ortholog
    USP6NL, USP6 N-terminal like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP6NL, USP6 N-terminal like
  • Synonyms
    RNTRE, TRE2NL, USP6NL-IT1
  • Links
    NCBI Gene ID: 9712
    neXtProt AC: NX_Q92738
    UniProt: Q92738

  • Chr Location
    10p14; chr10:11460510-11611666 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are viable, fertile and do not display gross abnormalities. However, primary embryonic fibroblast migration and chemotaxis are enhanced.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    10
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039046 Ensembl Gene Model | MGI Sequence Detail 123724 C57BL/6J ±  kb
transcript ENSMUST00000042503 Ensembl | MGI Sequence Detail 4340 Not Applicable  
polypeptide ENSMUSP00000043178 Ensembl | MGI Sequence Detail 842 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 3
References
more
  • Summaries
    All 36
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory