Eeig1 MGI Mouse Gene Detail - MGI:2138935 - estrogen-induced osteoclastogenesis regulator 1

Symbol

Eeig1
Name

estrogen-induced osteoclastogenesis regulator 1
Synonyms

C230093N12Rik, Fam102a

Feature Type

protein coding gene
IDs

MGI:2138935
NCBI Gene: 98952
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr2:32425344-32459763 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 22.09 cM
Mapping Data

2 experiments

SNPs within 2kb

820 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2138935	protein coding gene	Chr2:32425344-32459768 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025609	protein coding gene	Chr2:31006562-31044200 (+)
A/J	MGP_AJ_G0025586	protein coding gene	Chr2:29682566-29717097 (+)
AKR/J	MGP_AKRJ_G0025556	protein coding gene	Chr2:30747933-30782170 (+)
BALB/cJ	MGP_BALBcJ_G0025583	protein coding gene	Chr2:29807501-29842477 (+)
C3H/HeJ	MGP_C3HHeJ_G0025343	protein coding gene	Chr2:30636975-30671849 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026027	protein coding gene	Chr2:31948786-31984890 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023436	protein coding gene	Chr2:28402487-28437108 (+)
CAST/EiJ	MGP_CASTEiJ_G0024805	protein coding gene	Chr2:30576401-30611006 (+)
CBA/J	MGP_CBAJ_G0025321	protein coding gene	Chr2:33159217-33202172 (+)
DBA/2J	MGP_DBA2J_G0025454	protein coding gene	Chr2:29451166-29485394 (+)
FVB/NJ	MGP_FVBNJ_G0025416	protein coding gene	Chr2:29324860-29360403 (+)
LP/J	MGP_LPJ_G0025540	protein coding gene	Chr2:30877172-30919969 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025447	protein coding gene	Chr2:32800366-32835097 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026085	protein coding gene	Chr2:30625601-30660793 (+)
PWK/PhJ	MGP_PWKPhJ_G0024553	protein coding gene	Chr2:29354892-29390542 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024353	protein coding gene	Chr2:30780341-30815534 (+)
WSB/EiJ	MGP_WSBEiJ_G0024874	protein coding gene	Chr2:30802766-30837153 (+)

Human Ortholog

EEIG1, estrogen-induced osteoclastogenesis regulator 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EEIG1, estrogen-induced osteoclastogenesis regulator 1
Synonyms

bA203J24.7, C9orf132, FAM102A, SYM-3A
Links

HGNC:31419

NCBI Gene ID: 399665

neXtProt AC: NX_Q5T9C2

UniProt: Q5T9C2
Chr Location

chr9:127940582-127980989 (-) GRCh38

MGI Vertebrate Homology

Eeig1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: EEIG1
Gene Tree

Eeig1

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Gene trapped

4
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

14 strains or lines available

Homozygous knockout reduces susceptibility to inflammation-induced bone resorption by suppressing osteoclast formation.

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All GO Annotations

7
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

770
Tissues

9
cDNA Data

12
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FAM102A

Xenbase eeig1

ZFIN eeig1a

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All Sequences

66
RefSeq

2
UniProt

6
CCDS

CCDS15917.1

Ensembl

ENSMUSG00000039157 (Evidence)
NCBI Gene

98952

			Length	Strain/Species	Flank
genomic	98952	NCBI Gene Model \| MGI Sequence Detail	34420	C57BL/6J	± kb
transcript	NM_153560	RefSeq \| MGI Sequence Detail	4245	C57BL/6
polypeptide	Q78T81	UniProt \| EBI \| MGI Sequence Detail	392	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000031814 early estrogen-induced gene 1 protein

(term hierarchy)
InterPro Domains

IPR039931 EEIG1/2-like

IPR019448 NT-type C2 domain
GlyGen

Q78T81 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 12

cDNA 12

Microarray probesets 4

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MGI:7388572

Summaries

All 27

Developmental Gene Expression 2

Gene Ontology 2

Phenotypes 5
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:303193 Jeong E, et al., Early estrogen-induced gene 1 facilitates osteoclast formation through the inhibition of interferon regulatory factor 8 expression. FASEB J. 2020 Sep;34(9):12894-12906

TSS for Eeig1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17292	Chr2:32424598-32424614 (+)	-738 bp
Tssr17293	Chr2:32425294-32425302 (+)	-46 bp
Tssr17294	Chr2:32425327-32425359 (+)	-1 bp
Tssr17295	Chr2:32425408-32425417 (+)	69 bp
Tssr17296	Chr2:32425736-32425751 (+)	400 bp
Tssr17297	Chr2:32426060-32426067 (+)	720 bp
Tssr17298	Chr2:32455759-32455787 (+)	30,429 bp
Tssr17299	Chr2:32457742-32457782 (+)	32,418 bp
Tssr17300	Chr2:32457811-32457823 (+)	32,473 bp
Tssr17301	Chr2:32457944-32457957 (+)	32,607 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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