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Znfx1 Gene Detail
Summary
  • Symbol
    Znfx1
  • Name
    zinc finger, NFX1-type containing 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138982
    NCBI Gene: 98999
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:166877713-166904926 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 87.22 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    602 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138982
 protein coding gene Chr2:166877713-166904935 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026907
 protein coding gene Chr2:172735387-172762570 (-)
A/J MGP_AJ_G0026874
 protein coding gene Chr2:165640344-165666996 (-)
AKR/J MGP_AKRJ_G0026845
 protein coding gene Chr2:170570965-170597966 (-)
BALB/cJ MGP_BALBcJ_G0026883
 protein coding gene Chr2:165989383-166015920 (-)
C3H/HeJ MGP_C3HHeJ_G0026625
 protein coding gene Chr2:170938882-170966152 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027330
 protein coding gene Chr2:177754260-177780982 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024701
 protein coding gene Chr2:158967450-158994814 (-)
CAST/EiJ MGP_CASTEiJ_G0026083
 protein coding gene Chr2:171396784-171424719 (-)
CBA/J MGP_CBAJ_G0026602
 protein coding gene Chr2:184276669-184303280 (-)
DBA/2J MGP_DBA2J_G0026740
 protein coding gene Chr2:164761171-164787903 (-)
FVB/NJ MGP_FVBNJ_G0026706
 protein coding gene Chr2:163266678-163293579 (-)
LP/J MGP_LPJ_G0026841
 protein coding gene Chr2:172759437-172786406 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026725
 protein coding gene Chr2:187678044-187706175 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027387
 protein coding gene Chr2:170479199-170506638 (-)
PWK/PhJ MGP_PWKPhJ_G0025820
 protein coding gene Chr2:164413328-164440849 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025621
 protein coding gene Chr2:169424735-169455308 (-)
WSB/EiJ MGP_WSBEiJ_G0026156
 protein coding gene Chr2:171381703-171408697 (-)



Homology
more
  • Human Ortholog
    ZNFX1, zinc finger NFX1-type containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZNFX1, zinc finger NFX1-type containing 1
  • Synonyms
    IMD91
  • Links
    NCBI Gene ID: 57169
    neXtProt AC: NX_Q9P2E3
    UniProt: Q9P2E3

  • Chr Location
    20q13.13; chr20:49237946-49278426 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ZNFX1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    72
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 98999 NCBI Gene Model | MGI Sequence Detail 27214 C57BL/6J ±  kb
    transcript NM_001424669 RefSeq | MGI Sequence Detail 7452 C57BL/6  
    polypeptide Q8R151 UniProt | EBI | MGI Sequence Detail 1909 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 72
      cDNA 72

      Microarray probesets 3
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
    • Latest
      J:345967 Liu H, et al., ZNFX1 promotes AMPK-mediated autophagy against Mycobacterium tuberculosis by stabilizing Prkaa2 mRNA. JCI Insight. 2024 Jan 9;9(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory