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Olah Gene Detail
Summary
  • Symbol
    Olah
  • Name
    oleoyl-ACP hydrolase
  • Synonyms
    E230009B14Rik, Thedc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139018
    NCBI Gene: 99035
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:3343019-3367964 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 1.88 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    591 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139018
 protein coding gene Chr2:3343019-3398247 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025306
 protein coding gene Chr2:306188-368237 (-)
A/J MGP_AJ_G0025282
 protein coding gene Chr2:298034-349146 (-)
AKR/J MGP_AKRJ_G0025251
 protein coding gene Chr2:298427-358493 (-)
BALB/cJ MGP_BALBcJ_G0025278
 protein coding gene Chr2:279750-340357 (-)
C3H/HeJ MGP_C3HHeJ_G0025038
 protein coding gene Chr2:312221-369433 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025721
 protein coding gene Chr2:302707-360625 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023135
 protein coding gene Chr2:247818-296679 (-)
CAST/EiJ MGP_CASTEiJ_G0024502
 protein coding gene Chr2:298478-369774 (-)
CBA/J MGP_CBAJ_G0025018
 protein coding gene Chr2:328840-388946 (-)
DBA/2J MGP_DBA2J_G0025149
 protein coding gene Chr2:280084-334044 (-)
FVB/NJ MGP_FVBNJ_G0025111
 protein coding gene Chr2:293671-342998 (-)
LP/J MGP_LPJ_G0025236
 protein coding gene Chr2:315854-368410 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025144
 protein coding gene Chr2:308543-365011 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025779
 protein coding gene Chr2:312942-341062 (-)
PWK/PhJ MGP_PWKPhJ_G0024251
 protein coding gene Chr2:279661-332764 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024053
 protein coding gene Chr2:319614-384806 (-)
WSB/EiJ MGP_WSBEiJ_G0024572
 protein coding gene Chr2:309743-336601 (-)



Homology
more
  • Human Ortholog
    OLAH, oleoyl-ACP hydrolase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OLAH, oleoyl-ACP hydrolase
  • Synonyms
    AURA1, SAST, TE2, THEDC1
  • Links
    NCBI Gene ID: 55301
    neXtProt AC: NX_Q9NV23
    UniProt: Q9NV23

  • Chr Location
    10p13; chr10:15032195-15073853 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation show reduced susceptibility to Orthomyxoviridae infection, mild splenic hyperplasia, and urethral dilation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    816
  • Tissues
    98
  • cDNA Data
    20
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 99035 NCBI Gene Model | MGI Sequence Detail 24946 C57BL/6J ±  kb
    transcript NM_145921 RefSeq | MGI Sequence Detail 1522 C57BL/6  
    polypeptide Q8R197 UniProt | EBI | MGI Sequence Detail 265 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 20

      Microarray probesets 4
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 4
      Phenotypes 40
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:353571 Jia X, et al., High expression of oleoyl-ACP hydrolase underpins life-threatening respiratory viral diseases. Cell. 2024 Aug 22;187(17):4586-4604.e20
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory