Ssx2ip MGI Mouse Gene Detail - MGI:2139150 - SSX family member 2 interacting protein

Symbol

Ssx2ip
Name

SSX family member 2 interacting protein
Synonyms

Adip

Feature Type

protein coding gene
IDs

MGI:2139150
NCBI Gene: 99167
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:146110397-146145899 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 71.03 cM
Mapping Data

2 experiments

SNPs within 2kb

1186 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2139150	protein coding gene	Chr3:146110397-146145899 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027970	protein coding gene	Chr3:149913928-149955729 (+)
A/J	MGP_AJ_G0027929	protein coding gene	Chr3:144531087-144569190 (+)
AKR/J	MGP_AKRJ_G0027895	protein coding gene	Chr3:148395138-148430971 (+)
BALB/cJ	MGP_BALBcJ_G0027941	protein coding gene	Chr3:144359402-144394754 (+)
C3H/HeJ	MGP_C3HHeJ_G0027671	protein coding gene	Chr3:148756576-148796345 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028384	protein coding gene	Chr3:154941002-154979750 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025722	protein coding gene	Chr3:139597643-139633724 (+)
CAST/EiJ	MGP_CASTEiJ_G0027124	protein coding gene	Chr3:148736384-148772259 (+)
CBA/J	MGP_CBAJ_G0027646	protein coding gene	Chr3:160442499-160486254 (+)
DBA/2J	MGP_DBA2J_G0027786	protein coding gene	Chr3:143685328-143721018 (+)
FVB/NJ	MGP_FVBNJ_G0027753	protein coding gene	Chr3:141102967-141139493 (+)
LP/J	MGP_LPJ_G0027897	protein coding gene	Chr3:151291702-151329637 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027786	protein coding gene	Chr3:168720856-168760066 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028443	protein coding gene	Chr3:147977111-148014859 (+)
PWK/PhJ	MGP_PWKPhJ_G0026847	protein coding gene	Chr3:143540158-143576778 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026675	protein coding gene	Chr3:146145883-146181700 (+)
WSB/EiJ	MGP_WSBEiJ_G0027204	protein coding gene	Chr3:148947605-148985671 (+)

Human Ortholog

SSX2IP, SSX family member 2 interacting protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SSX2IP, SSX family member 2 interacting protein
Synonyms

ADIP, hMsd1
Links

HGNC:16509

NCBI Gene ID: 117178

neXtProt AC: NX_Q9Y2D8

UniProt: Q9Y2D8
Chr Location

1p22.3; chr1:84643706-84690803 (-) GRCh38

MGI Vertebrate Homology

Ssx2ip stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SSX2IP
Gene Tree

Ssx2ip

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

1
Gene trapped

13
Radiation induced

1
Genomic Mutations

1 involving Ssx2ip
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available

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All GO Annotations

31
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

11

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ssx2ip

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All Sequences

94
RefSeq

38
UniProt

5
CCDS

CCDS38665.1, CCDS57260.1

Ensembl

ENSMUSG00000036825 (Evidence)
NCBI Gene

99167

			Length	Strain/Species	Flank
genomic	99167	NCBI Gene Model \| MGI Sequence Detail	35503	C57BL/6J	± kb
transcript	NM_001411104	RefSeq \| MGI Sequence Detail	3701	C57BL/6
polypeptide	Q8VC66	UniProt \| EBI \| MGI Sequence Detail	615	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000015669 afadin- and alpha-actinin-binding protein

(term hierarchy)
InterPro Domains

IPR052300 Adhesion and Centrosome-associated Protein

IPR021622 Afadin/alpha-actinin-binding

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All nucleic 11

cDNA 11

Microarray probesets 7

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MGI:2139910

Summaries

All 40

Diseases 1

Gene Ontology 11

Phenotypes 9
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ssx2ip:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr32344	Chr3:146110386-146110493 (+)	43 bp
Tssr32345	Chr3:146110570-146110588 (+)	182 bp
Tssr32346	Chr3:146110599-146110632 (+)	219 bp
Tssr1085	Chr3:146110709-146110721 (+)	318 bp
Tssr32347	Chr3:146110763-146110785 (+)	377 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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