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Sec16a Gene Detail
Summary
  • Symbol
    Sec16a
  • Name
    SEC16 homolog A, endoplasmic reticulum export factor
  • Synonyms
    C230052J16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139207
    NCBI Gene: 227648
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:26299443-26335228 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 18.89 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    616 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139207
 protein coding gene Chr2:26299443-26336138 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025489
 protein coding gene Chr2:24360382-24399671 (-)
A/J MGP_AJ_G0025466
 protein coding gene Chr2:23426647-23462416 (-)
AKR/J MGP_AKRJ_G0025436
 protein coding gene Chr2:24189745-24227219 (-)
BALB/cJ MGP_BALBcJ_G0025462
 protein coding gene Chr2:23535639-23572155 (-)
C3H/HeJ MGP_C3HHeJ_G0025223
 protein coding gene Chr2:24148574-24185344 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025906
 protein coding gene Chr2:25143819-25182764 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023317
 protein coding gene Chr2:22306970-22344193 (-)
CAST/EiJ MGP_CASTEiJ_G0024686
 protein coding gene Chr2:24021949-24062037 (-)
CBA/J MGP_CBAJ_G0025201
 protein coding gene Chr2:25996800-26037179 (-)
DBA/2J MGP_DBA2J_G0025334
 protein coding gene Chr2:23248351-23283899 (-)
FVB/NJ MGP_FVBNJ_G0025296
 protein coding gene Chr2:23000001-23036140 (-)
LP/J MGP_LPJ_G0025420
 protein coding gene Chr2:24303644-24343188 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025327
 protein coding gene Chr2:26146846-26185182 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025965
 protein coding gene Chr2:24148169-24185304 (-)
PWK/PhJ MGP_PWKPhJ_G0024434
 protein coding gene Chr2:23051955-23088910 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024234
 protein coding gene Chr2:24280965-24318453 (-)
WSB/EiJ MGP_WSBEiJ_G0024755
 protein coding gene Chr2:24254469-24291112 (-)



Homology
more
  • Human Ortholog
    SEC16A, SEC16 homolog A, endoplasmic reticulum export factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEC16A, SEC16 homolog A, endoplasmic reticulum export factor
  • Synonyms
    KIAA0310, p250, SEC16L
  • Links
    NCBI Gene ID: 9919
    neXtProt AC: NX_O15027
    UniProt: O15027

  • Chr Location
    9q34.3; chr9:136440096-136484740 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    1
  • cDNA Data
    211
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026924 Ensembl Gene Model | MGI Sequence Detail 35786 C57BL/6J ±  kb
transcript ENSMUST00000114082 Ensembl | MGI Sequence Detail 8797 Not Applicable  
polypeptide ENSMUSP00000109716 Ensembl | MGI Sequence Detail 2377 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 211
    cDNA 211

    Microarray probesets 4
Other
Accession IDs
less
MGI:2443275
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 9
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:359007 Wang MJ, et al., SEC16A Variants Predispose to Chronic Pancreatitis by Impairing ER-to-Golgi Transport and Inducing ER Stress. Adv Sci (Weinh). 2024 Oct;11(38):e2402550
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory