Tmem62 MGI Mouse Gene Detail - MGI:2139461

Symbol

Tmem62
Name

transmembrane protein 62
Synonyms

B830009D23Rik

Feature Type

protein coding gene
IDs

MGI:2139461
NCBI Gene: 96957
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr2:120807498-120838333 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 60.37 cM
Mapping Data

2 experiments

SNPs within 2kb

685 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2139461	protein coding gene	Chr2:120806959-120838333 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026376	protein coding gene	Chr2:123849320-123884551 (+)
A/J	MGP_AJ_G0026337	protein coding gene	Chr2:118785266-118817033 (+)
AKR/J	MGP_AKRJ_G0026316	protein coding gene	Chr2:122114983-122149433 (+)
BALB/cJ	MGP_BALBcJ_G0026350	protein coding gene	Chr2:119020548-119051356 (+)
C3H/HeJ	MGP_C3HHeJ_G0026096	protein coding gene	Chr2:122603361-122636199 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026797	protein coding gene	Chr2:127920707-127952738 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024177	protein coding gene	Chr2:113828479-113859659 (+)
CAST/EiJ	MGP_CASTEiJ_G0025558	protein coding gene	Chr2:122913665-122950111 (+)
CBA/J	MGP_CBAJ_G0026072	protein coding gene	Chr2:132364941-132409271 (+)
DBA/2J	MGP_DBA2J_G0026211	protein coding gene	Chr2:118184826-118217629 (+)
FVB/NJ	MGP_FVBNJ_G0026173	protein coding gene	Chr2:117006282-117036999 (+)
LP/J	MGP_LPJ_G0026312	protein coding gene	Chr2:124113769-124145511 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026192	protein coding gene	Chr2:136675932-136709361 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026852	protein coding gene	Chr2:122236482-122269563 (+)
PWK/PhJ	MGP_PWKPhJ_G0025294	protein coding gene	Chr2:117786233-117817673 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025093	protein coding gene	Chr2:121453206-121486651 (+)
WSB/EiJ	MGP_WSBEiJ_G0025627	protein coding gene	Chr2:123064653-123096809 (+)

Human Ortholog

TMEM62, transmembrane protein 62

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM62, transmembrane protein 62
Links

HGNC:26269

NCBI Gene ID: 80021

neXtProt AC: NX_Q0P6H9

UniProt: Q0P6H9
Chr Location

15q15.2; chr15:43123279-43185144 (+) GRCh38

MGI Vertebrate Homology

Tmem62 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM62
Gene Tree

Tmem62

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

3
Radiation induced

1
Genomic Mutations

2 involving Tmem62
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

2
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

47

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem62

ZFIN tmem62

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All Sequences

52
RefSeq

5
UniProt

3
CCDS

CCDS16629.1

Ensembl

ENSMUSG00000054484 (Evidence)
NCBI Gene

96957

			Length	Strain/Species	Flank
genomic	ENSMUSG00000054484	Ensembl Gene Model \| MGI Sequence Detail	30836	C57BL/6J	± kb
transcript	ENSMUST00000067582	Ensembl \| MGI Sequence Detail	2921	Not Applicable
polypeptide	ENSMUSP00000064310	Ensembl \| MGI Sequence Detail	643	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000032190 transmembrane protein 62

(term hierarchy)
InterPro Domains

IPR004843 Calcineurin-like phosphoesterase domain, ApaH type

IPR029052 Metallo-dependent phosphatase-like

IPR041871 TMEM62, metallophosphatase domain
GlyGen

Q8BXJ9 4 sites, 5 N-linked glycans (4 sites)

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All nucleic 48

Genomic 1

cDNA 47

Microarray probesets 6

Summaries

All 31

Gene Ontology 2

Phenotypes 8
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tmem62:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19722	Chr2:120807562-120807588 (+)	77 bp
Tssr19723	Chr2:120807629-120807666 (+)	150 bp
Tssr19724	Chr2:120807729-120807789 (+)	261 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24