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Dpyd Gene Detail
Summary
  • Symbol
    Dpyd
  • Name
    dihydropyrimidine dehydrogenase
  • Synonyms
    DPD, E330028L06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139667
    NCBI Gene: 99586
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:118355778-119226573 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 51.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    23628 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139667
 protein coding gene Chr3:118355758-119226573 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027825
 protein coding gene Chr3:120597633-121523836 (+)
A/J MGP_AJ_G0027783
 protein coding gene Chr3:116634379-117527042 (+)
AKR/J MGP_AKRJ_G0027749
 protein coding gene Chr3:119563853-120485360 (+)
BALB/cJ MGP_BALBcJ_G0027795
 protein coding gene Chr3:116458145-117339473 (+)
C3H/HeJ MGP_C3HHeJ_G0027526
 protein coding gene Chr3:119981454-120885107 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028241
 protein coding gene Chr3:124986041-125960411 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025580
 protein coding gene Chr3:112197302-113046544 (+)
CAST/EiJ MGP_CASTEiJ_G0026982
 protein coding gene Chr3:119298280-120257540 (+)
CBA/J MGP_CBAJ_G0027501
 protein coding gene Chr3:129271952-130233612 (+)
DBA/2J MGP_DBA2J_G0027642
 protein coding gene Chr3:115825826-116701437 (+)
FVB/NJ MGP_FVBNJ_G0027610
 protein coding gene Chr3:113444965-114317881 (+)
LP/J MGP_LPJ_G0027752
 protein coding gene Chr3:122159008-123076129 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027640
 protein coding gene Chr3:136767191-137875645 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028297
 protein coding gene Chr3:119122330-120045340 (+)
PWK/PhJ MGP_PWKPhJ_G0026708
 protein coding gene Chr3:115471124-116343620 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026531
 protein coding gene Chr3:117169776-118082431 (+)
WSB/EiJ MGP_WSBEiJ_G0027062
 protein coding gene Chr3:119842533-120751519 (+)



Homology
more
  • Human Ortholog
    DPYD, dihydropyrimidine dehydrogenase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPYD, dihydropyrimidine dehydrogenase
  • Synonyms
    DHP, DHPDHASE, DPD, DYPD
  • Links
    NCBI Gene ID: 1806
    neXtProt AC: NX_Q12882
    UniProt: Q12882

  • Chr Location
    1p21.3; chr1:97077743-97995000 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human DPYD associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1030
  • Tissues
    170
  • cDNA Data
    28
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033308 Ensembl Gene Model | MGI Sequence Detail 870796 C57BL/6J ±  kb
    transcript ENSMUST00000039177 Ensembl | MGI Sequence Detail 4492 Not Applicable  
    polypeptide ENSMUSP00000039429 Ensembl | MGI Sequence Detail 1025 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000006678 dihydropyrimidine dehydrogenase [NADP(+)]
      (term hierarchy)
    • EC
      1.3.1.2
    • InterPro Domains
      IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site
      IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain
      IPR013785 Aldolase-type TIM barrel
      IPR009051 Alpha-helical ferredoxin
      IPR005720 Dihydroorotate dehydrogenase, catalytic
      IPR028261 Dihydroprymidine dehydrogenase domain II
      IPR023753 FAD/NAD(P)-binding domain
      IPR036188 FAD/NAD(P)-binding domain superfamily
    • GlyGen
      Q8CHR6 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 28
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 10
      Phenotypes 14
    • Earliest
      J:5178 Sanno Y, et al., Studies of a mutation affecting pyrimidine degradation in inbred mice. J Biol Chem. 1970 Nov 10;245(21):5668-76
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory