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Mexis Gene Detail
Summary
  • Symbol
    Mexis
  • Name
    macrophage expressed LXRa(NR1H3)-dependent amplifier of Abca1 transcription lncRNA
  • Synonyms
    AI427809, LOC381524
  • Feature Type
    lncRNA gene
  • IDs
    MGI:2140270
    NCBI Gene: 381524
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr4:53261356-53270232 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 28.60 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    435 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140270
 lncRNA gene Chr4:53261356-53270232 (-)
129S1/SvImJ MGP_129S1SvImJ_G0006424
 lincRNA gene Chr4:51883726-51892602 (-)
A/J MGP_AJ_G0006416
 lincRNA gene Chr4:49893113-49901987 (-)
AKR/J MGP_AKRJ_G0006390
 lincRNA gene Chr4:51259587-51268463 (-)
BALB/cJ MGP_BALBcJ_G0006390
 lincRNA gene Chr4:50079816-50088690 (-)
C3H/HeJ MGP_C3HHeJ_G0006340
 lincRNA gene Chr4:51812135-51821007 (-)
C57BL/6NJ MGP_C57BL6NJ_G0006556
 lincRNA gene Chr4:53799844-53808720 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0005843
 lincRNA gene Chr4:46865474-46874346 (-)
CAST/EiJ MGP_CASTEiJ_G0006274
 lincRNA gene Chr4:51460821-51469597 (-)
CBA/J MGP_CBAJ_G0006323
 lincRNA gene Chr4:55620675-55629541 (-)
DBA/2J MGP_DBA2J_G0006345
 lincRNA gene Chr4:49874885-49883759 (-)
FVB/NJ MGP_FVBNJ_G0006367
 lincRNA gene Chr4:49099893-49108769 (-)
LP/J MGP_LPJ_G0006426
 lincRNA gene Chr4:51988429-51997305 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0006354
 lincRNA gene Chr4:58871366-58880242 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0006560
 lincRNA gene Chr4:51494934-51503804 (-)
PWK/PhJ MGP_PWKPhJ_G0006210
 lincRNA gene Chr4:49826920-49835763 (-)
SPRET/EiJ MGP_SPRETEiJ_G0006123
 lincRNA gene Chr4:50786062-50794774 (-)
WSB/EiJ MGP_WSBEiJ_G0006319
 lincRNA gene Chr4:51395025-51403901 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    1 phenotype reference
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout affects macrophage cholesterol metabolism and increases atherosclerosis susceptibility in mice fed Western diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    16
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    9
Sequences &
Gene Models
less
  • All Sequences
    34
  • RefSeq
    3
  • UniProt
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic 381524 NCBI Gene Model | MGI Sequence Detail 8877 C57BL/6J ±  kb
transcript NR_033140 RefSeq | MGI Sequence Detail 2123 C57BL/6  
polypeptide Q3TAG4 UniProt | EBI | MGI Sequence Detail 104 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 1
Other
Accession IDs
less
MGI:2686505, MGI:6402049
References
more
  • Summaries
    All 14
    Gene Ontology 1
    Phenotypes 1
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:264834 Sallam T, et al., Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA. Nat Med. 2018 Mar;24(3):304-312
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory