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Rusc2 Gene Detail
Summary
  • Symbol
    Rusc2
  • Name
    RUN and SH3 domain containing 2
  • Synonyms
    mKIAA0375
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140371
    NCBI Gene: 100213
  • Alliance
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:43381979-43427088 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 4, 23.03 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1765 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140371
protein coding gene Chr4:43377202-43427088 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028203
protein coding gene Chr4:41484975-41535949 (+)
A/J MGP_AJ_G0028159
protein coding gene Chr4:40020167-40064739 (+)
AKR/J MGP_AKRJ_G0028111
protein coding gene Chr4:40933486-40978656 (+)
BALB/cJ MGP_BALBcJ_G0028179
protein coding gene Chr4:40109975-40155223 (+)
C3H/HeJ MGP_C3HHeJ_G0027901
protein coding gene Chr4:41554314-41601096 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028620
protein coding gene Chr4:43022606-43069903 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025932
protein coding gene Chr4:37471802-37518261 (+)
CAST/EiJ MGP_CASTEiJ_G0027341
protein coding gene Chr4:41060699-41107646 (+)
CBA/J MGP_CBAJ_G0027867
protein coding gene Chr4:44358944-44404082 (+)
DBA/2J MGP_DBA2J_G0028016
protein coding gene Chr4:39930079-39975243 (+)
FVB/NJ MGP_FVBNJ_G0027983
protein coding gene Chr4:39148657-39194569 (+)
LP/J MGP_LPJ_G0028115
protein coding gene Chr4:41547030-41593607 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028007
protein coding gene Chr4:47619455-47666720 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028656
protein coding gene Chr4:41123706-41168803 (+)
PWK/PhJ MGP_PWKPhJ_G0027067
protein coding gene Chr4:39967497-40021676 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026893
protein coding gene Chr4:40689564-40735511 (+)
WSB/EiJ MGP_WSBEiJ_G0027421
protein coding gene Chr4:41027817-41074479 (+)



Homology
more
  • Human Ortholog
    RUSC2, RUN and SH3 domain containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RUSC2, RUN and SH3 domain containing 2
  • Synonyms
    Iporin, MRT61
  • Links
    NCBI Gene ID: 9853
    neXtProt AC: NX_Q8N2Y8
    UniProt: Q8N2Y8

  • Chr Location
    9p13.3; chr9:35490111-35561898 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human RUSC2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035969 Ensembl Gene Model | MGI Sequence Detail 45110 C57BL/6J ±  kb
transcript ENSMUST00000035645 Ensembl | MGI Sequence Detail 5300 Not Applicable  
polypeptide ENSMUSP00000038379 Ensembl | MGI Sequence Detail 1523 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 103
    cDNA 103

    Microarray probesets 4
References
more
  • Summaries
    All 36
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:83413 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2003 Feb 28;10(1):35-48
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory