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Pramel12 Gene Detail
Summary
  • Symbol
    Pramel12
  • Name
    PRAME like 12
  • Synonyms
    4732496O08Rik, Pramef8
  • Feature Type
    protein coding gene
  • IDs
    MGI:2140473
    NCBI Gene: 242736
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr4:143138996-143147661 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 77.65 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    103 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2140473
 protein coding gene Chr4:143137457-143147661 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029069
 protein coding gene Chr4:146641348-146649822 (+)
A/J MGP_AJ_G0029029
 protein coding gene Chr4:140251265-140259928 (+)
AKR/J MGP_AKRJ_G0028981
 protein coding gene Chr4:144299813-144308465 (+)
BALB/cJ MGP_BALBcJ_G0029053
 protein coding gene Chr4:140918954-140927619 (+)
C3H/HeJ MGP_C3HHeJ_G0028767
 protein coding gene Chr4:144675013-144683680 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029494
 protein coding gene Chr4:151672798-151681465 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026764
 protein coding gene Chr4:133093996-133102945 (+)
CAST/EiJ MGP_CASTEiJ_G0028199
 protein coding gene Chr4:142975841-142984462 (+)
CBA/J MGP_CBAJ_G0028731
 protein coding gene Chr4:156230006-156238684 (+)
DBA/2J MGP_DBA2J_G0028881
 protein coding gene Chr4:140594799-140603451 (+)
FVB/NJ MGP_FVBNJ_G0028848
 protein coding gene Chr4:139762361-139771008 (+)
LP/J MGP_LPJ_G0028980
 protein coding gene Chr4:146674410-146683078 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028874
 protein coding gene Chr4:159883738-159892389 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029532
 protein coding gene Chr4:144843746-144852409 (+)
PWK/PhJ MGP_PWKPhJ_G0027921
 protein coding gene Chr4:137518674-137527338 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027744
 protein coding gene Chr4:140664719-140673886 (+)
WSB/EiJ MGP_WSBEiJ_G0028277
 protein coding gene Chr4:145144068-145152726 (+)



Homology
more
  • Human Ortholog
    PRAMEF13, PRAME family member 13
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRAMEF13, PRAME family member 13
  • Links
    NCBI Gene ID: 400736
    neXtProt AC: NX_Q5VWM6
    UniProt: Q5VWM6

  • Chr Location
    1p36.21; chr1:13196188-13201409 (-)  GRCh38
  • Human Ortholog
    PRAMEF7, PRAME family member 7
  • Links
    NCBI Gene ID: 441871
    neXtProt AC: NX_Q5VXH5
    UniProt: Q5VXH5

  • Chr Location
    1p36.21; chr1:12916610-12920751 (+)  GRCh38
  • Human Ortholog
    PRAMEF8, PRAME family member 8
  • Synonyms
    PRAMEF24
  • Links
    NCBI Gene ID: 391002
    neXtProt AC: NX_Q5VWM4
    UniProt: Q5VWM4

  • Chr Location
    1p36.21; chr1:13281304-13285137 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PRAME associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046862 Ensembl Gene Model | MGI Sequence Detail 8666 C57BL/6J ±  kb
    transcript ENSMUST00000059790 Ensembl | MGI Sequence Detail 3886 Not Applicable  
    polypeptide ENSMUSP00000058676 Ensembl | MGI Sequence Detail 480 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR032675 Leucine-rich repeat domain superfamily
      IPR026271 PRAME
      IPR050694 PRAME domain-containing protein
    Molecular
    Reagents
    less
    • All nucleic 7
      cDNA 7

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:6430508
    References
    more
    • Summaries
      All 30
      Gene Ontology 1
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory