Ppp1r8 MGI Mouse Gene Detail - MGI:2140494 - protein phosphatase 1, regulatory subunit 8

Symbol

Ppp1r8
Name

protein phosphatase 1, regulatory subunit 8
Synonyms

6330548N22Rik, NIPP1

Feature Type

protein coding gene
IDs

MGI:2140494
NCBI Gene: 100336
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr4:132554240-132570480 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 65.97 cM
Mapping Data

2 experiments

SNPs within 2kb

424 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2140494	protein coding gene	Chr4:132554235-132570480 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028881	protein coding gene	Chr4:135024973-135043000 (-)
A/J	MGP_AJ_G0028840	protein coding gene	Chr4:129397910-129414437 (-)
AKR/J	MGP_AKRJ_G0028793	protein coding gene	Chr4:133044911-133061277 (-)
BALB/cJ	MGP_BALBcJ_G0028863	protein coding gene	Chr4:130012277-130029500 (-)
C3H/HeJ	MGP_C3HHeJ_G0028577	protein coding gene	Chr4:133304770-133322097 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029305	protein coding gene	Chr4:139891311-139907594 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026576	protein coding gene	Chr4:122470014-122487898 (-)
CAST/EiJ	MGP_CASTEiJ_G0028010	protein coding gene	Chr4:131379980-131396101 (-)
CBA/J	MGP_CBAJ_G0028543	protein coding gene	Chr4:143476471-143492526 (-)
DBA/2J	MGP_DBA2J_G0028692	protein coding gene	Chr4:129813217-129829746 (-)
FVB/NJ	MGP_FVBNJ_G0028659	protein coding gene	Chr4:128678546-128696080 (-)
LP/J	MGP_LPJ_G0028793	protein coding gene	Chr4:135166898-135183103 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028685	protein coding gene	Chr4:148069497-148087896 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029343	protein coding gene	Chr4:133463064-133479253 (-)
PWK/PhJ	MGP_PWKPhJ_G0027731	protein coding gene	Chr4:126512813-126529096 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027557	protein coding gene	Chr4:129298425-129314633 (-)
WSB/EiJ	MGP_WSBEiJ_G0028090	protein coding gene	Chr4:133632350-133648462 (-)

Human Ortholog

PPP1R8, protein phosphatase 1 regulatory subunit 8

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPP1R8, protein phosphatase 1 regulatory subunit 8
Synonyms

ARD-1, ARD1, NIPP-1, NIPP1, PRO2047
Links

HGNC:9296

NCBI Gene ID: 5511

neXtProt AC: NX_Q12972

UniProt: Q12972
Chr Location

1p35.3; chr1:27830782-27851676 (+) GRCh38

MGI Vertebrate Homology

Ppp1r8 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PPP1R8
Gene Tree

Ppp1r8

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Phenotype Summary

21 phenotypes from 2 alleles in 2 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Chemically induced (other)

2
Gene trapped

24
Radiation induced

1
Targeted

5
Genomic Mutations

4 involving Ppp1r8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Embryos homozygous for knock-out allele exhibit severe growth retardation and impaired cell proliferation and die between embryonic days 6.5 and 7.5.

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All GO Annotations

16
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

719
Tissues

5
cDNA Data

48
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppp1r8

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All Sequences

49
RefSeq

8
UniProt

2
CCDS

CCDS18736.1, CCDS71482.1

Ensembl

ENSMUSG00000028882 (Evidence)
NCBI Gene

100336

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028882	Ensembl Gene Model \| MGI Sequence Detail	16241	C57BL/6J	± kb
transcript	ENSMUST00000030702	Ensembl \| MGI Sequence Detail	2037	Not Applicable
polypeptide	ENSMUSP00000030702	Ensembl \| MGI Sequence Detail	351	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013131 nuclear inhibitor of protein phosphatase 1

(term hierarchy)
PDB

2JPE
InterPro Domains

IPR050923 Cellular Process Regulator and RNA Processing Protein

IPR000253 Forkhead-associated (FHA) domain

IPR008984 SMAD/FHA domain superfamily

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All nucleic 51

cDNA 48

Primer pair 3

Microarray probesets 3

Summaries

All 49

Developmental Gene Expression 6

Gene Ontology 6

Phenotypes 18
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:347027 Jonkhout MCM, et al., Embryonic NIPP1 Depletion in Keratinocytes Triggers a Cell Cycle Arrest and Premature Senescence in Adult Mice. J Invest Dermatol. 2024 Feb 29;

TSS for Ppp1r8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr43719	Chr4:132570422-132570495 (-)	21 bp
Tssr43718	Chr4:132570254-132570256 (-)	225 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24