Acacb MGI Mouse Gene Detail - MGI:2140940 - acetyl-Coenzyme A carboxylase beta

Symbol

Acacb
Name

acetyl-Coenzyme A carboxylase beta
Synonyms

Acc2, Accb

Feature Type

protein coding gene
IDs

MGI:2140940
NCBI Gene: 100705
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr5:114284748-114388822 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 55.97 cM
Mapping Data

2 experiments

SNPs within 2kb

3548 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2140940	protein coding gene	Chr5:114284596-114388822 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029933	protein coding gene	Chr5:116859920-116971015 (+)
A/J	MGP_AJ_G0029898	protein coding gene	Chr5:112276820-112383377 (+)
AKR/J	MGP_AKRJ_G0029836	protein coding gene	Chr5:115842948-115951782 (+)
BALB/cJ	MGP_BALBcJ_G0029909	protein coding gene	Chr5:113645080-113751625 (+)
C3H/HeJ	MGP_C3HHeJ_G0029629	protein coding gene	Chr5:116335447-116454319 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030363	protein coding gene	Chr5:121379446-121500298 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027591	protein coding gene	Chr5:107101676-107208085 (+)
CAST/EiJ	MGP_CASTEiJ_G0029037	protein coding gene	Chr5:115268835-115385757 (+)
CBA/J	MGP_CBAJ_G0029596	protein coding gene	Chr5:125985784-126118305 (+)
DBA/2J	MGP_DBA2J_G0029746	protein coding gene	Chr5:112335970-112444723 (+)
FVB/NJ	MGP_FVBNJ_G0029703	protein coding gene	Chr5:111134056-111244999 (+)
LP/J	MGP_LPJ_G0029835	protein coding gene	Chr5:117428909-117539602 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029734	protein coding gene	Chr5:130454127-130571666 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030404	protein coding gene	Chr5:115301069-115416389 (+)
PWK/PhJ	MGP_PWKPhJ_G0028751	protein coding gene	Chr5:110966054-111074087 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028589	protein coding gene	Chr5:112844128-112954782 (+)
WSB/EiJ	MGP_WSBEiJ_G0029113	protein coding gene	Chr5:115866127-115983537 (+)

Human Ortholog

ACACB, acetyl-CoA carboxylase beta

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACACB, acetyl-CoA carboxylase beta
Synonyms

ACACbeta, ACC2, ACCB, ACC-beta, ACCbeta, HACC275
Links

HGNC:85

NCBI Gene ID: 32

neXtProt AC: NX_O00763

UniProt: O00763
Chr Location

12q24.11; chr12:109111189-109268226 (+) GRCh38

MGI Vertebrate Homology

Acacb stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ACACB
Gene Tree

Acacb

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Phenotype Summary

28 phenotypes from 4 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
46 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

6
Radiation induced

1
Targeted

9
Genomic Mutations

2 involving Acacb
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

109 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted null mutation are viable, fertile and overtly normal but exhibit high levels of fatty acid oxidation, as well as reduced fat accumulation in their adipose tissue and liver, and decreased storage of glycogen in their liver.

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All GO Annotations

56
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

809
Tissues

96
cDNA Data

10
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase acacb

ZFIN acacb

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All Sequences

55
RefSeq

12
UniProt

6
CCDS

CCDS19561.1

Ensembl

ENSMUSG00000042010 (Evidence)
NCBI Gene

100705

			Length	Strain/Species	Flank
genomic	100705	NCBI Gene Model \| MGI Sequence Detail	104075	C57BL/6J	± kb
transcript	NM_001403527	RefSeq \| MGI Sequence Detail	8699	C57BL/6
polypeptide	E9Q4Z2	UniProt \| EBI \| MGI Sequence Detail	2448	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000003597 acetyl-CoA carboxylase 2

(term hierarchy)
EC

6.4.1.2
InterPro Domains

IPR049076 Acetyl-CoA carboxylase

IPR049074 Acetyl-CoA carboxylase, BT domain

IPR013537 Acetyl-CoA carboxylase, central domain

IPR034733 Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta

IPR011763 Acetyl-coenzyme A carboxyltransferase, C-terminal

IPR011762 Acetyl-coenzyme A carboxyltransferase, N-terminal

IPR011761 ATP-grasp fold

IPR013815 ATP-grasp fold, subdomain 1

IPR005482 Biotin carboxylase, C-terminal

IPR005481 Biotin carboxylase-like, N-terminal domain

IPR011764 Biotin carboxylation domain

IPR000089 Biotin/lipoyl attachment

IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain

IPR029045 ClpP/crotonase-like domain superfamily

IPR016185 Pre-ATP-grasp domain superfamily

IPR011054 Rudiment single hybrid motif

IPR011053 Single hybrid motif
GlyGen

E9Q4Z2 1 site, 1 O-linked glycan (1 site)

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All nucleic 13

cDNA 10

Primer pair 3

Microarray probesets 4

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MGI:2141247

Summaries

All 97

Developmental Gene Expression 12

Gene Ontology 14

Phenotypes 46
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:346743 Deja S, et al., Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability. Cell Metab. 2024 Mar 1;

TSS for Acacb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48063	Chr5:114284354-114284378 (+)	-382 bp
Tssr48064	Chr5:114284385-114284404 (+)	-353 bp
Tssr48065	Chr5:114284501-114284510 (+)	-242 bp
Tssr48066	Chr5:114284562-114284575 (+)	-179 bp
Tssr48067	Chr5:114284586-114284611 (+)	-149 bp
Tssr48068	Chr5:114284627-114284671 (+)	-99 bp
Tssr48069	Chr5:114284736-114284776 (+)	8 bp
Tssr48070	Chr5:114284778-114284796 (+)	39 bp
Tssr48071	Chr5:114293487-114293494 (+)	8,743 bp
Tssr48072	Chr5:114293514-114293528 (+)	8,773 bp
Tssr48073	Chr5:114293532-114293576 (+)	8,806 bp
Tssr48074	Chr5:114313950-114313999 (+)	29,227 bp
Tssr48075	Chr5:114350105-114350110 (+)	65,360 bp
Tssr48076	Chr5:114386321-114386349 (+)	101,587 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24