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Kpna7 Gene Detail
Summary
  • Symbol
    Kpna7
  • Name
    karyopherin subunit alpha 7
  • Synonyms
    importin alpha 2, LOC381686
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141165
    NCBI Gene: 381686
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr5:144920537-144946446 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 84.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    987 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141165
 protein coding gene Chr5:144920329-145020840 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030354
 protein coding gene Chr5:150378043-150505518 (-)
A/J MGP_AJ_G0030323
 protein coding gene Chr5:143905526-144040032 (-)
AKR/J MGP_AKRJ_G0030255
 protein coding gene Chr5:148396019-148512354 (-)
BALB/cJ MGP_BALBcJ_G0030340
 protein coding gene Chr5:145184144-145294657 (-)
C3H/HeJ MGP_C3HHeJ_G0030051
 protein coding gene Chr5:149214133-149338825 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030785
 protein coding gene Chr5:155864986-155995385 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028004
 protein coding gene Chr5:137677854-137778098 (-)
CAST/EiJ MGP_CASTEiJ_G0029456
 protein coding gene Chr5:148780997-148903116 (-)
CBA/J MGP_CBAJ_G0030021
 protein coding gene Chr5:162259214-162432195 (-)
DBA/2J MGP_DBA2J_G0030171
 protein coding gene Chr5:143646547-143755677 (-)
FVB/NJ MGP_FVBNJ_G0030126
 protein coding gene Chr5:142866900-142902540 (-)
LP/J MGP_LPJ_G0030257
 protein coding gene Chr5:150965228-151088118 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030157
 protein coding gene Chr5:164593838-164738665 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030825
 protein coding gene Chr5:148301423-148413893 (-)
PWK/PhJ MGP_PWKPhJ_G0029171
 protein coding gene Chr5:142785799-142904711 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029007
 protein coding gene Chr5:146035064-146163757 (-)
WSB/EiJ MGP_WSBEiJ_G0029529
 protein coding gene Chr5:149097928-149222262 (-)



Homology
more
  • Human Ortholog
    KPNA7, karyopherin subunit alpha 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KPNA7, karyopherin subunit alpha 7
  • Synonyms
    IPOA8, OZEMA17
  • Links
    NCBI Gene ID: 402569
    neXtProt AC: NX_A9QM74
    UniProt: A9QM74

  • Chr Location
    chr7:99145804-99250075 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous or heterozygous for a null mutation display smaller litter sizes with preferential loss of females and accelerated cell cycles post fertilization resulting in loss of embryos.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    7
  • cDNA Data
    19
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 381686 NCBI Gene Model | MGI Sequence Detail 25910 C57BL/6J ±  kb
    transcript NM_001013774 RefSeq | MGI Sequence Detail 2248 Not Specified  
    polypeptide C0LLJ0 UniProt | EBI | MGI Sequence Detail 499 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 19
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2685901
    References
    more
    • Summaries
      All 28
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 3
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:332890 Wang W, et al., Karyopherin alpha deficiency contributes to human preimplantation embryo arrest. J Clin Invest. 2023 Jan 17;133(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory