Prkd2 MGI Mouse Gene Detail - MGI:2141917

Symbol

Prkd2
Name

protein kinase D2
Synonyms

PKD2

Feature Type

protein coding gene
IDs

MGI:2141917
NCBI Gene: 101540
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr7:16576827-16604386 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 9.15 cM
Mapping Data

1 experiment

SNPs within 2kb

874 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2141917	protein coding gene	Chr7:16576827-16604389 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031719	protein coding gene	Chr7:14593566-14631008 (+)
A/J	MGP_AJ_G0031691	protein coding gene	Chr7:14322881-14351204 (+)
AKR/J	MGP_AKRJ_G0031616	protein coding gene	Chr7:14661058-14689511 (+)
BALB/cJ	MGP_BALBcJ_G0031698	protein coding gene	Chr7:14432115-14459329 (+)
C3H/HeJ	MGP_C3HHeJ_G0031420	protein coding gene	Chr7:14843821-14876172 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032164	protein coding gene	Chr7:15329789-15354901 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029243	protein coding gene	Chr7:15859017-15887563 (+)
CAST/EiJ	MGP_CASTEiJ_G0030771	protein coding gene	Chr7:11617108-11645742 (+)
CBA/J	MGP_CBAJ_G0031379	protein coding gene	Chr7:15824892-15871544 (+)
DBA/2J	MGP_DBA2J_G0031535	protein coding gene	Chr7:14213373-14241932 (+)
FVB/NJ	MGP_FVBNJ_G0031491	protein coding gene	Chr7:14114005-14142010 (+)
LP/J	MGP_LPJ_G0031620	protein coding gene	Chr7:14834415-14868112 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031526	protein coding gene	Chr7:15757080-15788937 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032193	protein coding gene	Chr7:14435151-14470460 (+)
PWK/PhJ	MGP_PWKPhJ_G0030495	protein coding gene	Chr7:11732603-11763531 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030322	protein coding gene	Chr7:9363349-9392762 (+)
WSB/EiJ	MGP_WSBEiJ_G0030868	protein coding gene	Chr7:14507851-14535843 (+)

Human Ortholog

PRKD2, protein kinase D2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRKD2, protein kinase D2
Synonyms

HSPC187, nPKC-D2, PKD2
Links

HGNC:17293

NCBI Gene ID: 25865

neXtProt AC: NX_Q9BZL6

UniProt: Q9BZL6
Chr Location

19q13.32; chr19:46674275-46717127 (-) GRCh38

MGI Vertebrate Homology

Prkd2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PRKD2
Protein SuperFamily

PKC_mu_nu_D2
Gene Tree

Prkd2

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Phenotype Summary

14 phenotypes from 4 alleles in 4 genetic backgrounds
3 phenotypes from multigenic genotypes
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (ENU)

1
Endonuclease-mediated

7
Gene trapped

2
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-in allele exhibit impaired IgM and IgG1 antigen responses and CD4+ and CD8+ T cell production of IL2 and IFN-gamma in response to TCR stimulation. Mice homozygous for a gene trap allele exhibit normal T lymphocyte maturation.

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All GO Annotations

67
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

778
Tissues

38
cDNA Data

15
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

55
RefSeq

7
UniProt

2
CCDS

CCDS20855.1

Ensembl

ENSMUSG00000041187 (Evidence)
NCBI Gene

101540

			Length	Strain/Species	Flank
genomic	101540	NCBI Gene Model \| MGI Sequence Detail	27560	C57BL/6J	± kb
transcript	NM_178900	RefSeq \| MGI Sequence Detail	3625	C57BL/6
polypeptide	Q8BZ03	UniProt \| EBI \| MGI Sequence Detail	875	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013237 serine/threonine-protein kinase D2

(term hierarchy)
EC

2.7.11.13
InterPro Domains

IPR046349 C1-like domain superfamily

IPR020454 Diacylglycerol/phorbol-ester binding

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR017441 Protein kinase, ATP binding site

IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

IPR015727 Protein kinase C mu-related

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 17

cDNA 15

Primer pair 2

Microarray probesets 5

Summaries

All 58

Developmental Gene Expression 5

Gene Ontology 10

Phenotypes 21
Earliest

J:91812 Stryke D, et al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81
Latest

J:347799 Waheed-Ullah Q, et al., Effect of deletion of the protein kinase PRKD1 on development of the mouse embryonic heart. J Anat. 2024 Feb 28;

TSS for Prkd2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr64636	Chr7:16576821-16576879 (+)	23 bp
Tssr64637	Chr7:16576881-16576888 (+)	58 bp
Tssr64638	Chr7:16576895-16576941 (+)	91 bp
Tssr64639	Chr7:16576946-16576965 (+)	129 bp
Tssr64640	Chr7:16576974-16577002 (+)	161 bp
Tssr64641	Chr7:16577011-16577028 (+)	193 bp
Tssr64642	Chr7:16577100-16577136 (+)	291 bp
Tssr64643	Chr7:16578063-16578068 (+)	1,239 bp
Tssr64644	Chr7:16579736-16579751 (+)	2,917 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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