About   Help   FAQ
Whamm Gene Detail
Summary
  • Symbol
    Whamm
  • Name
    WAS protein homolog associated with actin, golgi membranes and microtubules
  • Synonyms
    Whdc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142282
    NCBI Gene: 434204
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:81221014-81246584 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 45.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    889 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142282
 protein coding gene Chr7:81220403-81246585 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032432
 protein coding gene Chr7:83639687-83666547 (+)
A/J MGP_AJ_G0032411
 protein coding gene Chr7:81662019-81687950 (+)
AKR/J MGP_AKRJ_G0032347
 protein coding gene Chr7:83466173-83495497 (+)
BALB/cJ MGP_BALBcJ_G0032423
 protein coding gene Chr7:81319736-81346528 (+)
C3H/HeJ MGP_C3HHeJ_G0032136
 protein coding gene Chr7:84083587-84110032 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032915
 protein coding gene Chr7:86906229-86936597 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029923
 protein coding gene Chr7:84134487-84168418 (+)
CAST/EiJ MGP_CASTEiJ_G0031464
 protein coding gene Chr7:75016725-75042621 (+)
CBA/J MGP_CBAJ_G0032102
 protein coding gene Chr7:89815413-89844265 (+)
DBA/2J MGP_DBA2J_G0032257
 protein coding gene Chr7:80191585-80219242 (+)
FVB/NJ MGP_FVBNJ_G0032212
 protein coding gene Chr7:80132044-80157322 (+)
LP/J MGP_LPJ_G0032338
 protein coding gene Chr7:84869787-84898056 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032249
 protein coding gene Chr7:89876149-89907719 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032933
 protein coding gene Chr7:82878260-82903909 (+)
PWK/PhJ MGP_PWKPhJ_G0031184
 protein coding gene Chr7:73406826-73432897 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031026
 protein coding gene Chr7:69887857-69927286 (+)
WSB/EiJ MGP_WSBEiJ_G0031582
 protein coding gene Chr7:83240751-83268119 (+)



Homology
more
  • Human Ortholog
    WHAMM, WASP homolog associated with actin, golgi membranes and microtubules
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WHAMM, WASP homolog associated with actin, golgi membranes and microtubules
  • Synonyms
    WHAMM1, WHDC1
  • Links
    NCBI Gene ID: 123720
    neXtProt AC: NX_Q8TF30
    UniProt: Q8TF30

  • Chr Location
    15q25.2; chr15:82809628-82836108 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Whamm mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male-specific abnormalities in kidney proximal tubule structure and reabsorption function with increased urinary levels of albumin, glucose, HAVCR1, phosphate, potassium and amino acids, and altered autophagy in kidney tissue. Mouse embryonic fibroblasts show altered autophagosome organization and actin recruitment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    755
  • Tissues
    42
  • cDNA Data
    10
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045795 Ensembl Gene Model | MGI Sequence Detail 25571 C57BL/6J ±  kb
    transcript ENSMUST00000165460 Ensembl | MGI Sequence Detail 3069 Not Applicable  
    polypeptide ENSMUSP00000128881 Ensembl | MGI Sequence Detail 793 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 3
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:349712 Coulter AM, et al., WHAMM functions in kidney reabsorption and polymerizes actin to promote autophagosomal membrane closure and cargo sequestration. Mol Biol Cell. 2024 Jun 1;35(6):ar80
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory