Mtmr10 MGI Mouse Gene Detail - MGI:2142292 - myotubularin related protein 10

Symbol

Mtmr10
Name

myotubularin related protein 10

Feature Type

protein coding gene
IDs

MGI:2142292
NCBI Gene: 233315
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr7:63937443-63990556 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 34.63 cM
Mapping Data

2 experiments

SNPs within 2kb

1529 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2142292	protein coding gene	Chr7:63937401-63990556 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032335	protein coding gene	Chr7:65423689-65478805 (+)
A/J	MGP_AJ_G0032314	protein coding gene	Chr7:64157703-64211356 (+)
AKR/J	MGP_AKRJ_G0032250	protein coding gene	Chr7:65512793-65567271 (+)
BALB/cJ	MGP_BALBcJ_G0032326	protein coding gene	Chr7:63898003-63950904 (+)
C3H/HeJ	MGP_C3HHeJ_G0032039	protein coding gene	Chr7:66159991-66217421 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032819	protein coding gene	Chr7:68228167-68301855 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029826	protein coding gene	Chr7:67103467-67156908 (+)
CAST/EiJ	MGP_CASTEiJ_G0031368	protein coding gene	Chr7:56856851-56911373 (+)
CBA/J	MGP_CBAJ_G0032005	protein coding gene	Chr7:70452682-70505755 (+)
DBA/2J	MGP_DBA2J_G0032161	protein coding gene	Chr7:62909567-62962936 (+)
FVB/NJ	MGP_FVBNJ_G0032115	protein coding gene	Chr7:63009038-63061954 (+)
LP/J	MGP_LPJ_G0032241	protein coding gene	Chr7:66656527-66716272 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032152	protein coding gene	Chr7:70726739-70780807 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032836	protein coding gene	Chr7:64794960-64850285 (+)
PWK/PhJ	MGP_PWKPhJ_G0031088	protein coding gene	Chr7:55918712-55972192 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030929	protein coding gene	Chr7:51932436-51986889 (+)
WSB/EiJ	MGP_WSBEiJ_G0031486	protein coding gene	Chr7:65178696-65233933 (+)

Human Ortholog

MTMR10, myotubularin related protein 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MTMR10, myotubularin related protein 10
Links

HGNC:25999

NCBI Gene ID: 54893

neXtProt AC: NX_Q9NXD2

UniProt: Q9NXD2
Chr Location

15q13.3; chr15:30918716-30991628 (-) GRCh38

MGI Vertebrate Homology

Mtmr10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MTMR10
Gene Tree

Mtmr10

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References

2 with disease annotations

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

2
Radiation induced

1
Targeted

7
Genomic Mutations

6 involving Mtmr10
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available

Mice homozygous for a null allele exhibit normal preweaning survival.

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All GO Annotations

6
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

796
Tissues

12
cDNA Data

83
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mtmr10

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All Sequences

57
RefSeq

4
UniProt

5
CCDS

CCDS39976.1

Ensembl

ENSMUSG00000030522 (Evidence)
NCBI Gene

233315

			Length	Strain/Species	Flank
genomic	233315	NCBI Gene Model \| MGI Sequence Detail	53114	C57BL/6J	± kb
transcript	NM_172742	RefSeq \| MGI Sequence Detail	5182	C57BL/6
polypeptide	Q7TPM9	UniProt \| EBI \| MGI Sequence Detail	771	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000010732 myotubularin-related protein 10

(term hierarchy)
InterPro Domains

IPR036004 MTMR10, PH-GRAM domain

IPR030564 Myotubularin family

IPR010569 Myotubularin-like, phosphatase domain

IPR022587 Myotubularin-related 12-like C-terminal domain

IPR030573 Myotubularin-related protein 10, protein tyrosine phosphatase domain

IPR011993 PH-like domain superfamily

IPR029021 Protein-tyrosine phosphatase-like
GlyGen

Q7TPM9 1 site, 1 N-linked glycan (1 site)

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All nucleic 83

cDNA 83

Microarray probesets 5

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MGI:2142333

Summaries

All 51

Developmental Gene Expression 2

Diseases 2

Gene Ontology 3

Phenotypes 25
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:348102 Unda BK, et al., Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome. Mol Psychiatry. 2023 Apr;28(4):1747-1769

TSS for Mtmr10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr67007	Chr7:63937217-63937251 (+)	-209 bp
Tssr67008	Chr7:63937401-63937410 (+)	-37 bp
Tssr67009	Chr7:63937413-63937424 (+)	-24 bp
Tssr67010	Chr7:63937425-63937463 (+)	1 bp
Tssr67011	Chr7:63937476-63937497 (+)	44 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24