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Nalf1 Gene Detail
Summary
  • Symbol
    Nalf1
  • Name
    NALCN channel auxiliary factor 1
  • Synonyms
    Fam155a
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142765
    NCBI Gene: 270028
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:9255902-9821161 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 3.90 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    16716 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142765
 protein coding gene Chr8:9255902-9823329 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033344
 protein coding gene Chr8:6308571-6904310 (-)
A/J MGP_AJ_G0033324
 protein coding gene Chr8:6103275-6666691 (-)
AKR/J MGP_AKRJ_G0033256
 protein coding gene Chr8:6288426-6870914 (-)
BALB/cJ MGP_BALBcJ_G0033325
 protein coding gene Chr8:6230147-6797299 (-)
C3H/HeJ MGP_C3HHeJ_G0033039
 protein coding gene Chr8:6444204-7036440 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033837
 protein coding gene Chr8:6585200-7204316 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030808
 protein coding gene Chr8:5691888-6224716 (-)
CAST/EiJ MGP_CASTEiJ_G0032361
 protein coding gene Chr8:6121139-6703595 (-)
CBA/J MGP_CBAJ_G0033012
 protein coding gene Chr8:6856445-7491376 (-)
DBA/2J MGP_DBA2J_G0033165
 protein coding gene Chr8:6109795-6666148 (-)
FVB/NJ MGP_FVBNJ_G0033113
 protein coding gene Chr8:6042608-6608990 (-)
LP/J MGP_LPJ_G0033259
 protein coding gene Chr8:6222934-6818591 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033148
 protein coding gene Chr8:7267159-7869396 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033854
 protein coding gene Chr8:6288930-6873930 (-)
PWK/PhJ MGP_PWKPhJ_G0032074
 protein coding gene Chr8:6046638-6609313 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031916
 protein coding gene Chr8:6193453-6760097 (-)
WSB/EiJ MGP_WSBEiJ_G0032477
 protein coding gene Chr8:6349826-6924578 (-)



Homology
more
  • Human Ortholog
    NALF1, NALCN channel auxiliary factor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NALF1, NALCN channel auxiliary factor 1
  • Synonyms
    FAM155A, NLF-1, NLF1
  • Links
    NCBI Gene ID: 728215
    neXtProt AC: NX_B1AL88
    UniProt: B1AL88

  • Chr Location
    13q33.3; chr13:107163510-107867496 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    748
  • Tissues
    9
  • cDNA Data
    23
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079157 Ensembl Gene Model | MGI Sequence Detail 565260 C57BL/6J ±  kb
    transcript ENSMUST00000110969 Ensembl | MGI Sequence Detail 3388 Not Applicable  
    polypeptide ENSMUSP00000106596 Ensembl | MGI Sequence Detail 467 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 24

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:6715964
    References
    more
    • Summaries
      All 27
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 4
    • Earliest
      J:93300 Blackshaw S, et al., Genomic analysis of mouse retinal development. PLoS Biol. 2004 Oct;2(9):E247
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory