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Tango6 Gene Detail
Summary
  • Symbol
    Tango6
  • Name
    transport and golgi organization 6
  • Synonyms
    Tango6, Tmco7
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142786
    NCBI Gene: 272538
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:107409700-107578071 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.18 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4636 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142786
 protein coding gene Chr8:107409697-107581175 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034086
 protein coding gene Chr8:109036244-109231750 (+)
A/J MGP_AJ_G0034067
 protein coding gene Chr8:104686113-104870739 (+)
AKR/J MGP_AKRJ_G0033993
 protein coding gene Chr8:107732232-107916897 (+)
BALB/cJ MGP_BALBcJ_G0034060
 protein coding gene Chr8:104881081-105062002 (+)
C3H/HeJ MGP_C3HHeJ_G0033772
 protein coding gene Chr8:108462684-108646911 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034580
 protein coding gene Chr8:113050776-113240710 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031522
 protein coding gene Chr8:97805564-97977946 (+)
CAST/EiJ MGP_CASTEiJ_G0033098
 protein coding gene Chr8:107977540-108166946 (+)
CBA/J MGP_CBAJ_G0033745
 protein coding gene Chr8:116681536-116892137 (+)
DBA/2J MGP_DBA2J_G0033900
 protein coding gene Chr8:104022390-104196113 (+)
FVB/NJ MGP_FVBNJ_G0033845
 protein coding gene Chr8:102966975-103135157 (+)
LP/J MGP_LPJ_G0033991
 protein coding gene Chr8:109242082-109430125 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033889
 protein coding gene Chr8:119842776-120030055 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034598
 protein coding gene Chr8:107664058-107845468 (+)
PWK/PhJ MGP_PWKPhJ_G0032800
 protein coding gene Chr8:103432646-103616836 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032640
 protein coding gene Chr8:106386834-106573697 (+)
WSB/EiJ MGP_WSBEiJ_G0033214
 protein coding gene Chr8:108376273-108561308 (+)



Homology
more
  • Human Ortholog
    TANGO6, transport and golgi organization 6 homolog
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TANGO6, transport and golgi organization 6 homolog
  • Synonyms
    TMCO7
  • Links
    NCBI Gene ID: 79613
    neXtProt AC: NX_Q9C0B7
    UniProt: Q9C0B7

  • Chr Location
    16q22.1; chr16:68843531-69085182 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    10
  • cDNA Data
    41
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041949 Ensembl Gene Model | MGI Sequence Detail 168372 C57BL/6J ±  kb
    transcript ENSMUST00000048359 Ensembl | MGI Sequence Detail 4409 Not Applicable  
    polypeptide ENSMUSP00000043953 Ensembl | MGI Sequence Detail 1079 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 41

      Microarray probesets 4
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 11
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:346124 Feng Z, et al., TANGO6 regulates cell proliferation via COPI vesicle-mediated RPB2 nuclear entry. Nat Commun. 2024 Mar 15;15(1):2371
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory