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Myzap Gene Detail
Summary
  • Symbol
    Myzap
  • Name
    myocardial zonula adherens protein
  • Synonyms
    Gcom1, Grinl1a7, Myozap
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142908
    NCBI Gene: 102371
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:71411629-71499642 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 39.85 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2424 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142908
 protein coding gene Chr9:71411629-71499642 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035010
 protein coding gene Chr9:71622520-71714715 (-)
A/J MGP_AJ_G0034991
 protein coding gene Chr9:69112114-69204146 (-)
AKR/J MGP_AKRJ_G0034920
 protein coding gene Chr9:70775269-70863662 (-)
BALB/cJ MGP_BALBcJ_G0034983
 protein coding gene Chr9:68833405-68922511 (-)
C3H/HeJ MGP_C3HHeJ_G0034692
 protein coding gene Chr9:71283588-71373855 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035502
 protein coding gene Chr9:73522427-73619723 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032413
 protein coding gene Chr9:68634159-68722847 (-)
CAST/EiJ MGP_CASTEiJ_G0034014
 protein coding gene Chr9:71565201-71658095 (-)
CBA/J MGP_CBAJ_G0034665
 protein coding gene Chr9:76064641-76159743 (-)
DBA/2J MGP_DBA2J_G0034824
 protein coding gene Chr9:68845172-68938119 (-)
FVB/NJ MGP_FVBNJ_G0034766
 protein coding gene Chr9:68166433-68254943 (-)
LP/J MGP_LPJ_G0034905
 protein coding gene Chr9:71836270-71928806 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034807
 protein coding gene Chr9:77125206-77222748 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035524
 protein coding gene Chr9:70909287-71004572 (-)
PWK/PhJ MGP_PWKPhJ_G0033718
 protein coding gene Chr9:69099672-69190619 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033551
 protein coding gene Chr9:71225865-71319094 (-)
WSB/EiJ MGP_WSBEiJ_G0034126
 protein coding gene Chr9:70848099-70938063 (-)



Homology
more
  • Human Ortholog
    GCOM1, GCOM1, MYZAP-POLR2M combined locus
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GCOM1, GCOM1, MYZAP-POLR2M combined locus
  • Synonyms
    gcom, Gcom2, GRINL1A, MYZAP, MYZAP-POLR2M
  • Links
    NCBI Gene ID: 145781
    neXtProt AC: NX_P0CAP1

  • Chr Location
    15q21.3; chr15:57591904-57717557 (+)  GRCh38
  • Human Ortholog
    MYZAP, myocardial zonula adherens protein
  • Synonyms
    CMD2K, GCOM1, Gup, MYOZAP
  • Links
    NCBI Gene ID: 100820829
    neXtProt AC: NX_P0CAP1
    UniProt: P0CAP1

  • Chr Location
    15q21.3; chr15:57591904-57685364 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous KO results in a maladaptive response to increased biomechanical stress, resulting in adverse cardiac remodeling, contractile dysfunction, heart failure, and increased mortality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    739
  • Tissues
    27
  • cDNA Data
    22
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 102371 NCBI Gene Model | MGI Sequence Detail 88014 C57BL/6J ±  kb
    transcript NM_001033208 RefSeq | MGI Sequence Detail 2283 C57BL/6  
    polypeptide Q3UIJ9 UniProt | EBI | MGI Sequence Detail 466 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 22

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143247
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory