About   Help   FAQ
Dennd4a Gene Detail
Summary
  • Symbol
    Dennd4a
  • Name
    DENN domain containing 4A
  • Synonyms
    F730015K02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2142979
    NCBI Gene: 102442
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:64718622-64826949 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 34.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2676 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2142979
 protein coding gene Chr9:64713408-64826949 (+)
129S1/SvImJ ENSMUSG00200040344
 protein coding gene Chr9:61821729-61930152 (+)
A/J ENSMUSG00195026101
 protein coding gene Chr9:61537376-61645673 (+)
AKR/J ENSMUSG00220035046
 protein coding gene Chr9:61681186-61789607 (+)
BALB/cJ ENSMUSG00180014711
 protein coding gene Chr9:61669407-61777834 (+)
C3H/HeJ ENSMUSG00175012070
 protein coding gene Chr9:61671113-61779405 (+)
C57BL/6NJ ENSMUSG00215016476
 protein coding gene Chr9:61656488-61764906 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032347
 protein coding gene Chr9:61974643-62086422 (+)
CAST/EiJ ENSTCUG00005029896
 protein coding gene Chr9:61566988-61674691 (+)
CBA/J ENSMUSG00210013686
 protein coding gene Chr9:61752502-61860911 (+)
DBA/2J ENSMUSG00185029694
 protein coding gene Chr9:61776133-61884543 (+)
FVB/NJ ENSMUSG00205018390
 protein coding gene Chr9:62101194-62209858 (+)
JF1/MsJ ENSUMUG00000014020
 protein coding gene Chr9:61828632-61937860 (+)
LP/J ENSMUSG00230023331
 protein coding gene Chr9:62020808-62129226 (+)
NOD/ShiLtJ ENSMUSG00190018800
 protein coding gene Chr9:61865499-61973787 (+)
NZO/HlLtJ ENSMUSG00225043988
 protein coding gene Chr9:62089241-62197630 (+)
PWK/PhJ ENSLUMG00010023182
 protein coding gene Chr9:61799320-61908323 (+)
SPRET/EiJ ENSMSPG00010020334
 protein coding gene Chr9:62875742-62961189 (+)
WSB/EiJ ENSIUOG00005023966
 protein coding gene Chr9:61264022-61372786 (+)



Homology
more
  • Human Ortholog
    DENND4A, DENN domain containing 4A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DENND4A, DENN domain containing 4A
  • Synonyms
    IRLB, MYCPBP
  • Links
    NCBI Gene ID: 10260
    UniProt: Q7Z401

  • Chr Location
    15q22.31; chr15:65658046-65792293 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    619
  • Tissues
    2
  • cDNA Data
    62
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053641 Ensembl Gene Model | MGI Sequence Detail 108328 C57BL/6J ±  kb
transcript ENSMUST00000038890 Ensembl | MGI Sequence Detail 8645 Not Applicable  
polypeptide ENSMUSP00000037915 Ensembl | MGI Sequence Detail 1869 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 62
    cDNA 62

    Microarray probesets 11
Other
Accession IDs
less
MGI:2143156, MGI:2442199
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:323637 Enikanolaiye A, et al., Suppressor mutations in Mecp2-null mice implicate the DNA damage response in Rett syndrome pathology. Genome Res. 2020 Apr;30(4):540-552
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory