Mapkapk3 MGI Mouse Gene Detail - MGI:2143163 - mitogen-activated protein kinase-activated protein kinase 3

Symbol

Mapkapk3
Name

mitogen-activated protein kinase-activated protein kinase 3
Synonyms

MK3

Feature Type

protein coding gene
IDs

MGI:2143163
NCBI Gene: 102626
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr9:107132126-107167076 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 57.98 cM
Mapping Data

1 experiment

SNPs within 2kb

963 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2143163	protein coding gene	Chr9:107132125-107167082 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035248	protein coding gene	Chr9:109111335-109146256 (-)
A/J	MGP_AJ_G0035227	protein coding gene	Chr9:105149671-105185525 (-)
AKR/J	MGP_AKRJ_G0035159	protein coding gene	Chr9:107769645-107808850 (-)
BALB/cJ	MGP_BALBcJ_G0035221	protein coding gene	Chr9:104818826-104854723 (-)
C3H/HeJ	MGP_C3HHeJ_G0034931	protein coding gene	Chr9:108168412-108206378 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035741	protein coding gene	Chr9:112106568-112147552 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032639	protein coding gene	Chr9:102578926-102614319 (-)
CAST/EiJ	MGP_CASTEiJ_G0034242	protein coding gene	Chr9:108094983-108136497 (-)
CBA/J	MGP_CBAJ_G0034899	protein coding gene	Chr9:116084784-116119742 (-)
DBA/2J	MGP_DBA2J_G0035060	protein coding gene	Chr9:104602205-104644551 (-)
FVB/NJ	MGP_FVBNJ_G0035008	protein coding gene	Chr9:103362091-103396711 (-)
LP/J	MGP_LPJ_G0035136	protein coding gene	Chr9:109317605-109354391 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035047	protein coding gene	Chr9:117670269-117708930 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035762	protein coding gene	Chr9:108036781-108073004 (-)
PWK/PhJ	MGP_PWKPhJ_G0033949	protein coding gene	Chr9:104914551-104951113 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033784	protein coding gene	Chr9:108097937-108138889 (-)
WSB/EiJ	MGP_WSBEiJ_G0034363	protein coding gene	Chr9:107923384-107960696 (-)

Human Ortholog

MAPKAPK3, MAPK activated protein kinase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAPKAPK3, MAPK activated protein kinase 3
Synonyms

3PK, MAPKAP3, MAPKAP-K3, MAPKAPK-3, MDPT3, MK-3, MK3
Links

HGNC:6888

NCBI Gene ID: 7867

neXtProt AC: NX_Q16644

UniProt: Q16644
Chr Location

3p21.2; chr3:50611520-50649291 (+) GRCh38

MGI Vertebrate Homology

Mapkapk3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MAPKAPK3
Gene Tree

Mapkapk3

Diseases

1 with human MAPKAPK3 associations

				Human Disease	Mouse Models
				patterned macular dystrophy 3 IDs patterned macular dystrophy 3 DOID:0060865 OMIM:617111

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
3 phenotypes from multigenic genotypes
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Endonuclease-mediated

4
Gene trapped

12
Targeted

4
Incidental Mutations

CvDC
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are viable and fertile and display normal tissue morphology, behavior, and LPS-induced production of cytokines. Eyes of homozygous null mice show defects in Bruch's membrane, with disorganized architecture and variability in thickness.

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All GO Annotations

25
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

960
Tissues

37
cDNA Data

11
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mapkapk3

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All Sequences

64
RefSeq

14
UniProt

4
CCDS

CCDS23487.1, CCDS85722.1

Ensembl

ENSMUSG00000032577 (Evidence)
NCBI Gene

102626

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032577	Ensembl Gene Model \| MGI Sequence Detail	34951	C57BL/6J	± kb
transcript	ENSMUST00000035194	Ensembl \| MGI Sequence Detail	2816	Not Applicable
polypeptide	ENSMUSP00000035194	Ensembl \| MGI Sequence Detail	384	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010166 MAP kinase-activated protein kinase 3

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR050205 Calcium-dependent Serine/Threonine Protein Kinases

IPR027442 MAP kinase activated protein kinase, C-terminal

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 14

cDNA 11

Primer pair 3

Microarray probesets 3

Summaries

All 61

Developmental Gene Expression 4

Gene Ontology 10

Phenotypes 28
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mapkapk3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr91373	Chr9:107167046-107167065 (-)	20 bp
Tssr91372	Chr9:107167033-107167044 (-)	37 bp
Tssr91371	Chr9:107167005-107167017 (-)	65 bp
Tssr91370	Chr9:107166905-107166985 (-)	131 bp
Tssr91369	Chr9:107166701-107166716 (-)	367 bp
Tssr91368	Chr9:107166668-107166679 (-)	402 bp
Tssr91367	Chr9:107166590-107166621 (-)	470 bp
Tssr91366	Chr9:107158026-107158070 (-)	9,028 bp
Tssr91365	Chr9:107157879-107157899 (-)	9,187 bp
Tssr91364	Chr9:107157863-107157872 (-)	9,208 bp
Tssr91363	Chr9:107138230-107138249 (-)	28,836 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24