Klhl18 MGI Mouse Gene Detail - MGI:2143315

Symbol

Klhl18
Name

kelch-like 18
Synonyms

MGC:36415

Feature Type

protein coding gene
IDs

MGI:2143315
NCBI Gene: 270201
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr9:110254994-110305762 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 59.92 cM
Mapping Data

1 experiment

SNPs within 2kb

1397 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2143315	protein coding gene	Chr9:110254994-110305768 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035348	protein coding gene	Chr9:112572695-112633673 (-)
A/J	MGP_AJ_G0035329	protein coding gene	Chr9:108483857-108535806 (-)
AKR/J	MGP_AKRJ_G0035260	protein coding gene	Chr9:111178961-111233627 (-)
BALB/cJ	MGP_BALBcJ_G0035324	protein coding gene	Chr9:108231441-108281196 (-)
C3H/HeJ	MGP_C3HHeJ_G0035032	protein coding gene	Chr9:111685217-111741046 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035846	protein coding gene	Chr9:115628946-115685694 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032732	protein coding gene	Chr9:105705353-105755926 (-)
CAST/EiJ	MGP_CASTEiJ_G0034337	protein coding gene	Chr9:111460290-111522501 (-)
CBA/J	MGP_CBAJ_G0034999	protein coding gene	Chr9:119935035-119996651 (-)
DBA/2J	MGP_DBA2J_G0035158	protein coding gene	Chr9:107950446-107998280 (-)
FVB/NJ	MGP_FVBNJ_G0035105	protein coding gene	Chr9:106772767-106824470 (-)
LP/J	MGP_LPJ_G0035237	protein coding gene	Chr9:112873190-112926597 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035145	protein coding gene	Chr9:121291377-121341078 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035866	protein coding gene	Chr9:111509817-111562622 (-)
PWK/PhJ	MGP_PWKPhJ_G0034045	protein coding gene	Chr9:108189555-108241794 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033880	protein coding gene	Chr9:111597332-111651256 (-)
WSB/EiJ	MGP_WSBEiJ_G0034459	protein coding gene	Chr9:111382836-111432609 (-)

Human Ortholog

KLHL18, kelch like family member 18

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KLHL18, kelch like family member 18
Links

HGNC:29120

NCBI Gene ID: 23276

neXtProt AC: NX_O94889

UniProt: O94889
Chr Location

3p21.31; chr3:47282917-47346816 (+) GRCh38

MGI Vertebrate Homology

Klhl18 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KLHL18
Protein SuperFamily

Kelch-like_protein_gigaxonin
Gene Tree

Klhl18

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Phenotype Summary

9 phenotypes from 2 alleles in 3 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Spontaneous

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit progressive increase in auditory brain stem response with tapered inner hair cell stereocilia.

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

772
Tissues

11
cDNA Data

56
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase klhl18

ZFIN klhl18

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All Sequences

71
RefSeq

10
UniProt

10
CCDS

CCDS23567.1, CCDS90672.1

Ensembl

ENSMUSG00000054792 (Evidence)
NCBI Gene

270201

			Length	Strain/Species	Flank
genomic	ENSMUSG00000054792	Ensembl Gene Model \| MGI Sequence Detail	50769	C57BL/6J	± kb
transcript	ENSMUST00000198164	Ensembl \| MGI Sequence Detail	4538	Not Applicable
polypeptide	ENSMUSP00000143634	Ensembl \| MGI Sequence Detail	579	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000009380 kelch-like protein 18

(term hierarchy)
InterPro Domains

IPR011705 BTB/Kelch-associated

IPR017096 BTB-kelch protein

IPR000210 BTB/POZ domain

IPR011043 Galactose oxidase/kelch, beta-propeller

IPR030603 Kelch-like protein 18, BTB/POZ domain

IPR006652 Kelch repeat type 1

IPR015915 Kelch-type beta propeller

IPR011333 SKP1/BTB/POZ domain superfamily

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All nucleic 57

cDNA 57

Microarray probesets 4

Summaries

All 32

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 7
Earliest

J:82808 Strausberg RL, et al., Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Klhl18:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr91629	Chr9:110305705-110305716 (-)	51 bp
Tssr91628	Chr9:110305672-110305695 (-)	78 bp
Tssr91627	Chr9:110291504-110291521 (-)	14,249 bp
Tssr91626	Chr9:110291490-110291499 (-)	14,267 bp
Tssr91625	Chr9:110290123-110290155 (-)	15,623 bp
Tssr91624	Chr9:110288303-110288314 (-)	17,453 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24