About   Help   FAQ
Fig4 Gene Detail
Summary
  • Symbol
    Fig4
  • Name
    FIG4 phosphoinositide 5-phosphatase
  • Synonyms
    A530089I17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143585
    NCBI Gene: 103199
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:41064168-41179237 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 22.08 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3025 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2143585
 protein coding gene Chr10:41064168-41179256 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017170
 protein coding gene Chr10:39830169-39951433 (-)
A/J MGP_AJ_G0017147
 protein coding gene Chr10:38722496-38837474 (-)
AKR/J MGP_AKRJ_G0017107
 protein coding gene Chr10:39289978-39410465 (-)
BALB/cJ MGP_BALBcJ_G0017109
 protein coding gene Chr10:38791057-38904689 (-)
C3H/HeJ MGP_C3HHeJ_G0016930
 protein coding gene Chr10:39600910-39718962 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017568
 protein coding gene Chr10:41044108-41164290 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015264
 protein coding gene Chr10:36664721-36779021 (-)
CAST/EiJ MGP_CASTEiJ_G0016509
 protein coding gene Chr10:39811045-39926806 (-)
CBA/J MGP_CBAJ_G0016904
 protein coding gene Chr10:42914500-43034746 (-)
DBA/2J MGP_DBA2J_G0017009
 protein coding gene Chr10:38222354-38336259 (-)
FVB/NJ MGP_FVBNJ_G0017004
 protein coding gene Chr10:37715092-37827609 (-)
LP/J MGP_LPJ_G0017086
 protein coding gene Chr10:39814928-39938217 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017034
 protein coding gene Chr10:43741427-43857318 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017605
 protein coding gene Chr10:39255807-39382632 (-)
PWK/PhJ MGP_PWKPhJ_G0016289
 protein coding gene Chr10:38108366-38221003 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016073
 protein coding gene Chr10:39090182-39200875 (-)
WSB/EiJ MGP_WSBEiJ_G0016572
 protein coding gene Chr10:39599262-39717708 (-)



Homology
more
  • Human Ortholog
    FIG4, FIG4 phosphoinositide 5-phosphatase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FIG4, FIG4 phosphoinositide 5-phosphatase
  • Synonyms
    ALS11, BOP, BTOP, CMT4J, dJ249I4.1, KIAA0274, SAC3, YVS
  • Links
    NCBI Gene ID: 9896
    neXtProt AC: NX_Q92562
    UniProt: Q92562

  • Chr Location
    6q21; chr6:109690609-109878098 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Fig4 mouse models; 4 with human FIG4 associations

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    55 phenotypes from 6 alleles in 5 genetic backgrounds
    1 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous allele exhibit premature death, severe tremors, diluted coat color, neurodegeneration, impaired coordination, muscle weakness, small size and reduced spleen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    777
  • Tissues
    19
  • cDNA Data
    56
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 103199 NCBI Gene Model | MGI Sequence Detail 115070 C57BL/6J ±  kb
    transcript NM_133999 RefSeq | MGI Sequence Detail 3278 FVB/N  
    polypeptide Q91WF7 UniProt | EBI | MGI Sequence Detail 907 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 56
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 3
      Diseases 3
      Gene Ontology 10
      Phenotypes 32
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:337201 Cao X, et al., Altered phenotypes due to genetic interaction between the mouse phosphoinositide biosynthesis genes Fig4 and Pip4k2c. G3 (Bethesda). 2023 Jan 24;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory