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Traf3ip2 Gene Detail
Summary
  • Symbol
    Traf3ip2
  • Name
    TRAF3 interacting protein 2
  • Synonyms
    Act1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143599
    NCBI Gene: 103213
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:39488930-39531303 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 20.86 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1166 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2143599
 protein coding gene Chr10:39488930-39531303 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017152
 protein coding gene Chr10:38130578-38175361 (+)
A/J MGP_AJ_G0017129
 protein coding gene Chr10:37112261-37155381 (+)
AKR/J MGP_AKRJ_G0017089
 protein coding gene Chr10:37626229-37671160 (+)
BALB/cJ MGP_BALBcJ_G0017092
 protein coding gene Chr10:37156131-37198213 (+)
C3H/HeJ MGP_C3HHeJ_G0016912
 protein coding gene Chr10:37952943-37999606 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017550
 protein coding gene Chr10:39296707-39344840 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015247
 protein coding gene Chr10:35100247-35140525 (+)
CAST/EiJ MGP_CASTEiJ_G0016491
 protein coding gene Chr10:38108533-38155156 (+)
CBA/J MGP_CBAJ_G0016886
 protein coding gene Chr10:41114958-41164023 (+)
DBA/2J MGP_DBA2J_G0016991
 protein coding gene Chr10:36632881-36675702 (+)
FVB/NJ MGP_FVBNJ_G0016986
 protein coding gene Chr10:36138167-36180080 (+)
LP/J MGP_LPJ_G0017068
 protein coding gene Chr10:38098199-38143417 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017016
 protein coding gene Chr10:41962622-42007839 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017587
 protein coding gene Chr10:37617077-37661820 (+)
PWK/PhJ MGP_PWKPhJ_G0016272
 protein coding gene Chr10:36473471-36518873 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016056
 protein coding gene Chr10:37398324-37451513 (+)
WSB/EiJ MGP_WSBEiJ_G0016554
 protein coding gene Chr10:37892080-37937242 (+)



Homology
more
  • Human Ortholog
    TRAF3IP2, TRAF3 interacting protein 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRAF3IP2, TRAF3 interacting protein 2
  • Synonyms
    ACT1, C6orf2, C6orf4, C6orf5, C6orf6, CANDF8, CIKS, PSORS13
  • Links
    NCBI Gene ID: 10758
    neXtProt AC: NX_O43734
    UniProt: O43734

  • Chr Location
    6q21; chr6:111555381-111606906 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with Traf3ip2 mouse models; 2 with human TRAF3IP2 associations

Human Disease Mouse Models
      
IDs
 View 5 models
IDs
 View 1 model
IDs
 View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    59 phenotypes from 5 alleles in 11 genetic backgrounds
    45 phenotypes from multigenic genotypes
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele exhibit splenomegaly, lymphadenopathy, increased number of B cells, defective IL-17 signaling, and increased immunoglobulin levels (including auto-antibodies) whereas mice homozygous for another null allele lack these features except the defect in IL-17 signaling.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    82
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    50
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 103213 NCBI Gene Model | MGI Sequence Detail 42374 C57BL/6J ±  kb
    transcript NM_134000 RefSeq | MGI Sequence Detail 2867 C57BL/6  
    polypeptide Q8N7N6 UniProt | EBI | MGI Sequence Detail 555 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 50

      Microarray probesets 3
    References
    more
    • Summaries
      All 94
      Diseases 4
      Gene Ontology 25
      Phenotypes 58
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:341717 Taylor TC, et al., IkappaBzeta is an essential mediator of immunity to oropharyngeal candidiasis. Cell Host Microbe. 2023 Oct 11;31(10):1700-1713.e4
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory