Zfp365 MGI Mouse Gene Detail - MGI:2143676

Symbol

Zfp365
Name

zinc finger protein 365
Synonyms

DBZ, mKIAA0844, Su48

Feature Type

protein coding gene
IDs

MGI:2143676
NCBI Gene: 216049
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:67721935-67748492 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 35.04 cM
Mapping Data

1 experiment

SNPs within 2kb

899 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2143676	protein coding gene	Chr10:67721933-67748492 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017327	protein coding gene	Chr10:67675532-67702040 (-)
A/J	MGP_AJ_G0017304	protein coding gene	Chr10:65404289-65430820 (-)
AKR/J	MGP_AKRJ_G0017265	protein coding gene	Chr10:67187270-67214243 (-)
BALB/cJ	MGP_BALBcJ_G0017264	protein coding gene	Chr10:65612876-65639415 (-)
C3H/HeJ	MGP_C3HHeJ_G0017088	protein coding gene	Chr10:67188041-67214617 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017722	protein coding gene	Chr10:70107419-70135782 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015412	protein coding gene	Chr10:62090621-62117380 (-)
CAST/EiJ	MGP_CASTEiJ_G0016658	protein coding gene	Chr10:67244965-67271622 (-)
CBA/J	MGP_CBAJ_G0017060	protein coding gene	Chr10:72786485-72813044 (-)
DBA/2J	MGP_DBA2J_G0017165	protein coding gene	Chr10:64787811-64814285 (-)
FVB/NJ	MGP_FVBNJ_G0017158	protein coding gene	Chr10:63946901-63976560 (-)
LP/J	MGP_LPJ_G0017238	protein coding gene	Chr10:68086396-68117254 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017186	protein coding gene	Chr10:74985102-75014170 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017761	protein coding gene	Chr10:67085629-67112197 (-)
PWK/PhJ	MGP_PWKPhJ_G0016442	protein coding gene	Chr10:64590362-64617445 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016224	protein coding gene	Chr10:66464628-66493304 (-)
WSB/EiJ	MGP_WSBEiJ_G0016722	protein coding gene	Chr10:67026315-67053731 (-)

Human Ortholog

ZNF365, zinc finger protein 365

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF365, zinc finger protein 365
Synonyms

Su48, UAN, ZNF365D
Links

HGNC:18194

NCBI Gene ID: 22891

neXtProt AC: NX_Q70YC4, NX_Q70YC5

UniProt: Q70YC4, Q70YC5
Chr Location

10q21.2; chr10:62374192-62480288 (+) GRCh38

MGI Vertebrate Homology

Zfp365 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZNF365
Gene Tree

Zfp365

Diseases

1 with human ZNF365 associations

				Human Disease	Mouse Models
				uric acid nephrolithiasis IDs uric acid nephrolithiasis DOID:580 ICD9CM_2006:274.11 ICD9CM:274.11 NCI:C123245 OMIM:605990 UMLS_CUI:C0403719

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Gene trapped

1
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Zfp365
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit abnormal cortical basket cells in the somatosensory cortices, delayed myelination in the corpus callosum during the early postnatal period, and an increase in immature oligodendrocytes.

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All GO Annotations

24
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

737
Tissues

18
cDNA Data

41
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN znf365

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All Sequences

47
RefSeq

2
UniProt

3
CCDS

CCDS23903.1

Ensembl

ENSMUSG00000037855 (Evidence)
NCBI Gene

216049

			Length	Strain/Species	Flank
genomic	216049	NCBI Gene Model \| MGI Sequence Detail	26558	C57BL/6J	± kb
transcript	NM_178679	RefSeq \| MGI Sequence Detail	4279	C57BL/6
polypeptide	Q8BG89	UniProt \| EBI \| MGI Sequence Detail	408	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000018256 ZNF365 gene translation product

(term hierarchy)
InterPro Domains

IPR052283 Genomic Stability and Neuronal Morphogenesis Regulator

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All nucleic 45

cDNA 41

Primer pair 4

Microarray probesets 5

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MGI:2143789

Summaries

All 47

Developmental Gene Expression 6

Gene Ontology 10

Phenotypes 18
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zfp365:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr97976	Chr10:67748450-67748515 (-)	9 bp
Tssr97975	Chr10:67748424-67748447 (-)	56 bp
Tssr97974	Chr10:67748305-67748322 (-)	178 bp
Tssr97973	Chr10:67748228-67748290 (-)	233 bp
Tssr97972	Chr10:67737093-67737100 (-)	11,395 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24