Mgat4b MGI Mouse Gene Detail - MGI:2143974 - mannoside acetylglucosaminyltransferase 4, isoenzyme B

Symbol

Mgat4b
Name

mannoside acetylglucosaminyltransferase 4, isoenzyme B

Feature Type

protein coding gene
IDs

MGI:2143974
NCBI Gene: 103534
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:50116162-50125930 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 30.37 cM
Mapping Data

1 experiment

SNPs within 2kb

254 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2143974	protein coding gene	Chr11:50101717-50125930 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018244	protein coding gene	Chr11:49377256-49403714 (+)
A/J	MGP_AJ_G0018212	protein coding gene	Chr11:47483286-47507642 (+)
AKR/J	MGP_AKRJ_G0018182	protein coding gene	Chr11:48994312-49019533 (+)
BALB/cJ	MGP_BALBcJ_G0018182	protein coding gene	Chr11:47762632-47787006 (+)
C3H/HeJ	MGP_C3HHeJ_G0017995	protein coding gene	Chr11:49000695-49025717 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018633	protein coding gene	Chr11:50839386-50866525 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016285	protein coding gene	Chr11:45102602-45127573 (+)
CAST/EiJ	MGP_CASTEiJ_G0017557	protein coding gene	Chr11:48969897-48997730 (+)
CBA/J	MGP_CBAJ_G0017970	protein coding gene	Chr11:53199959-53224042 (+)
DBA/2J	MGP_DBA2J_G0018077	protein coding gene	Chr11:47282689-47306926 (+)
FVB/NJ	MGP_FVBNJ_G0018071	protein coding gene	Chr11:46907553-46933287 (+)
LP/J	MGP_LPJ_G0018152	protein coding gene	Chr11:49710648-49738621 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018096	protein coding gene	Chr11:54725997-54753954 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018677	protein coding gene	Chr11:49101119-49128865 (+)
PWK/PhJ	MGP_PWKPhJ_G0017335	protein coding gene	Chr11:47682719-47711028 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017130	protein coding gene	Chr11:48796421-48820443 (+)
WSB/EiJ	MGP_WSBEiJ_G0017610	protein coding gene	Chr11:48740497-48766380 (+)

Human Ortholog

MGAT4B, alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MGAT4B, alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B
Synonyms

GNT-IV, GNT-IVB
Links

HGNC:7048

NCBI Gene ID: 11282

neXtProt AC: NX_Q9UQ53

UniProt: Q9UQ53
Chr Location

5q35.3; chr5:179797597-179806952 (-) GRCh38

MGI Vertebrate Homology

Mgat4b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MGAT4B
Gene Tree

Mgat4b

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

4
Targeted

2
Genomic Mutations

1 involving Mgat4b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a floxed targeted allele are viable and do not display any gross physical or behavioral abnormalities.

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All GO Annotations

14
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

838
Tissues

102
cDNA Data

71
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

69
RefSeq

2
UniProt

3
CCDS

CCDS24630.1

Ensembl

ENSMUSG00000036620 (Evidence)
NCBI Gene

103534

			Length	Strain/Species	Flank
genomic	103534	NCBI Gene Model \| MGI Sequence Detail	9769	C57BL/6J	± kb
transcript	NM_145926	RefSeq \| MGI Sequence Detail	2429	C57BL/6
polypeptide	Q812F8	UniProt \| EBI \| MGI Sequence Detail	548	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010382 alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

(term hierarchy)
EC

2.4.1.145
InterPro Domains

IPR006759 Glycosyl transferase family 54
GlyGen

Q812F8 3 sites, 2 N-linked glycans (2 sites)

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All nucleic 71

cDNA 71

Microarray probesets 2

Summaries

All 32

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 8
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Mgat4b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101230	Chr11:50115575-50115587 (+)	-581 bp
Tssr101231	Chr11:50115895-50115914 (+)	-257 bp
Tssr101232	Chr11:50116135-50116138 (+)	-25 bp
Tssr101233	Chr11:50116142-50116256 (+)	37 bp
Tssr101234	Chr11:50116302-50116319 (+)	149 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24