Tmem17 MGI Mouse Gene Detail - MGI:2144205

Symbol

Tmem17
Name

transmembrane protein 17

Feature Type

protein coding gene
IDs

MGI:2144205
NCBI Gene: 103765
Alliance

gene page

Sequence Map

Chr11:22462283-22469231 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 14.17 cM
Mapping Data

1 experiment

SNPs within 2kb

345 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2144205	protein coding gene	Chr11:22462088-22469234 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018077	protein coding gene	Chr11:20186234-20194846 (+)
A/J	MGP_AJ_G0018050	protein coding gene	Chr11:19432177-19439323 (+)
AKR/J	MGP_AKRJ_G0018014	protein coding gene	Chr11:20124948-20132092 (+)
BALB/cJ	MGP_BALBcJ_G0018018	protein coding gene	Chr11:19569425-19576807 (+)
C3H/HeJ	MGP_C3HHeJ_G0017832	protein coding gene	Chr11:20009456-20017240 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018470	protein coding gene	Chr11:21052444-21060426 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016128	protein coding gene	Chr11:18346551-18353927 (+)
CAST/EiJ	MGP_CASTEiJ_G0017393	protein coding gene	Chr11:20047886-20055514 (+)
CBA/J	MGP_CBAJ_G0017806	protein coding gene	Chr11:21967738-21977983 (+)
DBA/2J	MGP_DBA2J_G0017916	protein coding gene	Chr11:19367999-19377857 (+)
FVB/NJ	MGP_FVBNJ_G0017908	protein coding gene	Chr11:19138793-19145903 (+)
LP/J	MGP_LPJ_G0017987	protein coding gene	Chr11:20325523-20336490 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017934	protein coding gene	Chr11:22456810-22464922 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018511	protein coding gene	Chr11:20239582-20247799 (+)
PWK/PhJ	MGP_PWKPhJ_G0017174	protein coding gene	Chr11:19404012-19411220 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016971	protein coding gene	Chr11:19977577-19984543 (+)
WSB/EiJ	MGP_WSBEiJ_G0017447	protein coding gene	Chr11:19857648-19866944 (+)

Human Ortholog

TMEM17, transmembrane protein 17

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEM17, transmembrane protein 17
Links

HGNC:26623

NCBI Gene ID: 200728

neXtProt AC: NX_Q86X19

UniProt: Q86X19
Chr Location

2p15; chr2:62453531-62511894 (-) GRCh38

MGI Vertebrate Homology

Tmem17 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMEM17
Gene Tree

Tmem17

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

1
Genomic Mutations

1 involving Tmem17
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

19
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

13
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmem17, tmem17l

ZFIN tmem17

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All Sequences

31
RefSeq

2
UniProt

1
CCDS

CCDS24470.1

Ensembl

ENSMUSG00000049904 (Evidence)
NCBI Gene

103765

			Length	Strain/Species	Flank
genomic	103765	NCBI Gene Model \| MGI Sequence Detail	6949	C57BL/6J	± kb
transcript	NM_153596	RefSeq \| MGI Sequence Detail	1370	C57BL/6
polypeptide	Q8K0U3	UniProt \| EBI \| MGI Sequence Detail	198	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031255 transmembrane protein 17

(term hierarchy)
InterPro Domains

IPR019184 Uncharacterised protein family, transmembrane-17
GlyGen

Q8K0U3 1 site, 1 N-linked glycan (1 site)

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All nucleic 13

cDNA 13

Microarray probesets 4

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MGI:2144488

Summaries

All 29

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 8
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:178978 Chih B, et al., A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain. Nat Cell Biol. 2011;14(1):61-72

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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