Nsrp1 MGI Mouse Gene Detail - MGI:2144305 - nuclear speckle regulatory protein 1

Symbol

Nsrp1
Name

nuclear speckle regulatory protein 1
Synonyms

Ccdc55, NSpr70

Feature Type

protein coding gene
IDs

MGI:2144305
NCBI Gene: 237859
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:76935118-76969261 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 46.21 cM
Mapping Data

1 experiment

SNPs within 2kb

920 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2144305	protein coding gene	Chr11:76935118-76969263 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018743	protein coding gene	Chr11:77908546-77947094 (-)
A/J	MGP_AJ_G0018709	protein coding gene	Chr11:74983953-75018438 (-)
AKR/J	MGP_AKRJ_G0018679	protein coding gene	Chr11:77253055-77288463 (-)
BALB/cJ	MGP_BALBcJ_G0018683	protein coding gene	Chr11:75365866-75400116 (-)
C3H/HeJ	MGP_C3HHeJ_G0018496	protein coding gene	Chr11:77275387-77311486 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019134	protein coding gene	Chr11:80364957-80401485 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016769	protein coding gene	Chr11:71973956-72007461 (-)
CAST/EiJ	MGP_CASTEiJ_G0018050	protein coding gene	Chr11:77680988-77717442 (-)
CBA/J	MGP_CBAJ_G0018466	protein coding gene	Chr11:83861469-83899450 (-)
DBA/2J	MGP_DBA2J_G0018575	protein coding gene	Chr11:74573686-74608660 (-)
FVB/NJ	MGP_FVBNJ_G0018565	protein coding gene	Chr11:74137371-74171912 (-)
LP/J	MGP_LPJ_G0018646	protein coding gene	Chr11:78513278-78552004 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018591	protein coding gene	Chr11:84326080-84367048 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019174	protein coding gene	Chr11:77467746-77504197 (-)
PWK/PhJ	MGP_PWKPhJ_G0017821	protein coding gene	Chr11:75318306-75353195 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017612	protein coding gene	Chr11:77052743-77096540 (-)
WSB/EiJ	MGP_WSBEiJ_G0018103	protein coding gene	Chr11:77283213-77318936 (-)

Human Ortholog

NSRP1, nuclear speckle splicing regulatory protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NSRP1, nuclear speckle splicing regulatory protein 1
Synonyms

CCDC55, HSPC095, NEDSSBA, NSrp70
Links

HGNC:25305

NCBI Gene ID: 84081

neXtProt AC: NX_Q9H0G5

UniProt: Q9H0G5
Chr Location

17q11.2; chr17:30115521-30186475 (+) GRCh38

MGI Vertebrate Homology

Nsrp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NSRP1
Gene Tree

Nsrp1

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Phenotype Summary

14 phenotypes from 3 alleles in 3 genetic backgrounds
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

48
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

40
Targeted

5
Genomic Mutations

2 involving Nsrp1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele die prior to E6.5. Homozygous KO in lymphocytes affects alternative splicing of pre-mRNA splicing factors and other genes, which leads to reduced numbers of mature T cells.

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All GO Annotations

16
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

727
Tissues

20
cDNA Data

39
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nsrp1

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All Sequences

53
RefSeq

2
UniProt

6
CCDS

CCDS25075.1

Ensembl

ENSMUSG00000037958 (Evidence)
NCBI Gene

237859

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037958	Ensembl Gene Model \| MGI Sequence Detail	34144	C57BL/6J	± kb
transcript	ENSMUST00000102494	Ensembl \| MGI Sequence Detail	3114	Not Applicable
polypeptide	ENSMUSP00000099552	Ensembl \| MGI Sequence Detail	542	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000029652 nuclear speckle splicing regulatory protein 1

(term hierarchy)
InterPro Domains

IPR042816 Nuclear speckle splicing regulatory protein 1

IPR018612 Nuclear speckle splicing regulatory protein 1, N-terminal

IPR046850 Nuclear speckle splicing regulatory protein 1, RS-like domain
GlyGen

Q5NCR9 1 site, 1 O-linked glycan (1 site)

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All nucleic 40

cDNA 39

Primer pair 1

Microarray probesets 5

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MGI:2144344

Summaries

All 44

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 22
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:306261 Kim CH, et al., NSrp70 is a lymphocyte-essential splicing factor that controls thymocyte development. Nucleic Acids Res. 2021 Jun 4;49(10):5760-5778

TSS for Nsrp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr109321	Chr11:76969230-76969268 (-)	12 bp
Tssr109320	Chr11:76937293-76937311 (-)	31,959 bp
Tssr109319	Chr11:76937068-76937080 (-)	32,187 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24