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Cbll1 Gene Detail
Summary
  • Symbol
    Cbll1
  • Name
    Casitas B-lineage lymphoma-like 1
  • Synonyms
    c-Cbl-like, Hakai
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144842
    NCBI Gene: 104836
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:31534828-31549615 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 13.49 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    371 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144842
 protein coding gene Chr12:31534828-31550536 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019661
 protein coding gene Chr12:29438233-29456208 (-)
A/J MGP_AJ_G0019628
 protein coding gene Chr12:28602039-28616729 (-)
AKR/J MGP_AKRJ_G0019599
 protein coding gene Chr12:29518342-29533048 (-)
BALB/cJ MGP_BALBcJ_G0019605
 protein coding gene Chr12:28825293-28841339 (-)
C3H/HeJ MGP_C3HHeJ_G0019409
 protein coding gene Chr12:29384844-29403349 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020052
 protein coding gene Chr12:30344394-30359165 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017677
 protein coding gene Chr12:27888455-27902458 (-)
CAST/EiJ MGP_CASTEiJ_G0018964
 protein coding gene Chr12:24375224-24391861 (-)
CBA/J MGP_CBAJ_G0019381
 protein coding gene Chr12:31317329-31333801 (-)
DBA/2J MGP_DBA2J_G0019494
 protein coding gene Chr12:28435428-28450424 (-)
FVB/NJ MGP_FVBNJ_G0019485
 protein coding gene Chr12:28227942-28242613 (-)
LP/J MGP_LPJ_G0019564
 protein coding gene Chr12:29529200-29547974 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019520
 protein coding gene Chr12:30978676-30996653 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020092
 protein coding gene Chr12:29038723-29053912 (-)
PWK/PhJ MGP_PWKPhJ_G0018731
 protein coding gene Chr12:23156926-23172410 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018519
 protein coding gene Chr12:23631227-23646038 (-)
WSB/EiJ MGP_WSBEiJ_G0019014
 protein coding gene Chr12:29276051-29291241 (-)



Homology
more
  • Human Ortholog
    CBLL1, Cbl proto-oncogene like 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CBLL1, Cbl proto-oncogene like 1
  • Synonyms
    HAKAI, RNF188
  • Links
    NCBI Gene ID: 79872
    neXtProt AC: NX_Q75N03
    UniProt: Q75N03

  • Chr Location
    7q22.3; chr7:107743073-107761667 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    717
  • Tissues
    1
  • cDNA Data
    15
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020659 Ensembl Gene Model | MGI Sequence Detail 14788 C57BL/6J ±  kb
transcript ENSMUST00000101499 Ensembl | MGI Sequence Detail 3900 Not Applicable  
polypeptide ENSMUSP00000099038 Ensembl | MGI Sequence Detail 491 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 6
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 11
    Phenotypes 6
  • Earliest
    J:83415 Fujita Y, et al., Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat Cell Biol. 2002 Mar;4(3):222-31
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory