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Zfyve16 Gene Detail
Summary
  • Symbol
    Zfyve16
  • Name
    zinc finger, FYVE domain containing 16
  • Synonyms
    B130024H06Rik, mKIAA0305
  • Feature Type
    protein coding gene
  • IDs
    MGI:2145181
    NCBI Gene: 218441
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:92624257-92667318 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 47.72 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1200 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2145181
 protein coding gene Chr13:92623616-92667376 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020817
 protein coding gene Chr13:93790803-93839948 (-)
A/J MGP_AJ_G0020771
 protein coding gene Chr13:90330154-90374909 (-)
AKR/J MGP_AKRJ_G0020744
 protein coding gene Chr13:93055759-93101734 (-)
BALB/cJ MGP_BALBcJ_G0020767
 protein coding gene Chr13:90964609-91009000 (-)
C3H/HeJ MGP_C3HHeJ_G0020561
 protein coding gene Chr13:92768911-92819629 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021204
 protein coding gene Chr13:96645563-96694551 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018771
 protein coding gene Chr13:86245333-86294901 (-)
CAST/EiJ MGP_CASTEiJ_G0020080
 protein coding gene Chr13:92025324-92073038 (-)
CBA/J MGP_CBAJ_G0020520
 protein coding gene Chr13:100494573-100548313 (-)
DBA/2J MGP_DBA2J_G0020645
 protein coding gene Chr13:90077877-90121363 (-)
FVB/NJ MGP_FVBNJ_G0020625
 protein coding gene Chr13:88902951-88947125 (-)
LP/J MGP_LPJ_G0020718
 protein coding gene Chr13:93913181-93959531 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020654
 protein coding gene Chr13:100985403-101035240 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021244
 protein coding gene Chr13:92463371-92507555 (-)
PWK/PhJ MGP_PWKPhJ_G0019832
 protein coding gene Chr13:88830520-88874205 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019656
 protein coding gene Chr13:88721881-88769012 (-)
WSB/EiJ MGP_WSBEiJ_G0020137
 protein coding gene Chr13:92943363-92989673 (-)



Homology
more
  • Human Ortholog
    ZFYVE16, zinc finger FYVE-type containing 16
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZFYVE16, zinc finger FYVE-type containing 16
  • Synonyms
    PPP1R69
  • Links
    NCBI Gene ID: 9765
    neXtProt AC: NX_Q7Z3T8
    UniProt: Q7Z3T8

  • Chr Location
    5q14.1; chr5:80407610-80483379 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased common lymphocyte progenitor cell number in the bone marrow, increased T cell number in peripheral blood, and decreased B cell proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    783
  • Tissues
    32
  • cDNA Data
    44
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 218441 NCBI Gene Model | MGI Sequence Detail 43062 C57BL/6J ±  kb
transcript NM_173392 RefSeq | MGI Sequence Detail 5451 C57BL/6  
polypeptide Q80U44 UniProt | EBI | MGI Sequence Detail 1528 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 44
    cDNA 44

    Microarray probesets 2
References
more
  • Summaries
    All 32
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:302014 Zhao X, et al., Zfyve16 regulates the proliferation of B-lymphoid cells. Front Med. 2018 Oct;12(5):559-565
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory